{"id":"pycnogenol","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":{"setId":"ff0f9055-7b12-479f-8c66-469084921e18","title":"PYCNOGENOL 6X LIQUID [BIOACTIVE NUTRITIONAL, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pycnogenol, derived from French maritime pine bark, contains a complex mixture of flavonoids and proanthocyanidins that scavenge free radicals and inhibit inflammatory pathways. 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Menorrhagia, Menopausal, Menopause","enrollment":40},{"nctId":"NCT00425945","phase":"NA","title":"Understanding Pine Bark Extract as an Alternative Treatment (UPBEAT) Study","status":"COMPLETED","sponsor":"Stanford University","startDate":"2006-10","conditions":"Hypertension","enrollment":130},{"nctId":"NCT00641758","phase":"NA","title":"Pycnogenol and Endothelial Function in Coronary Artery Disease","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2008-03","conditions":"Coronary Artery Disease","enrollment":25}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":510,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Pycnogenol®","genericName":"Pycnogenol®","companyName":"University of Zurich","companyId":"university-of-zurich","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pycnogenol is a plant extract rich in proanthocyanidins that acts as an antioxidant and anti-inflammatory agent, reducing oxidative stress and vascular inflammation. 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