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Purified inactivated rabies vaccine
Purified inactivated rabies vaccine is a Vaccine Biologic drug developed by Sanofi Pasteur, a Sanofi Company. It is currently in Phase 3 development for Rabies post-exposure prophylaxis, Rabies pre-exposure prophylaxis in high-risk individuals. Also known as: Verorab®, Verorab.
Purified inactivated rabies vaccine stimulates the immune system to produce antibodies and cellular immunity against rabies virus, preventing infection after exposure.
Purified inactivated rabies vaccine stimulates the immune system to produce antibodies and cellular immunity against rabies virus, preventing infection after exposure. Used for Rabies post-exposure prophylaxis, Rabies pre-exposure prophylaxis in high-risk individuals.
At a glance
| Generic name | Purified inactivated rabies vaccine |
|---|---|
| Also known as | Verorab®, Verorab |
| Sponsor | Sanofi Pasteur, a Sanofi Company |
| Drug class | Vaccine |
| Modality | Biologic |
| Therapeutic area | Immunology / Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
The vaccine contains inactivated (killed) rabies virus particles that trigger both humoral (antibody) and cell-mediated immune responses without causing disease. Upon exposure to rabies virus, the pre-existing immunity provides rapid neutralization of the virus before it can reach the central nervous system. This is typically administered post-exposure in combination with rabies immunoglobulin for non-vaccinated individuals, or as pre-exposure prophylaxis for high-risk populations.
Approved indications
- Rabies post-exposure prophylaxis
- Rabies pre-exposure prophylaxis in high-risk individuals
Common side effects
- Injection site reactions (pain, erythema, swelling)
- Headache
- Myalgia
- Fever
- Nausea
Key clinical trials
- A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 With Matrix-M in Combination With R21/Matrix-M (PHASE2)
- Study of Purified Vero Rabies Vaccine Compared With Two Reference Rabies Vaccines, Given in a Pre-exposure Regimen to Children and Adults and as Single Booster Dose to a Subset of Adults (PHASE3)
- Pfs230D1 + R21 in Matrix-M1 in African School Children and Adults (PHASE2)
- Study of Purified Vero Rabies Vaccine Compared With a Reference Rabies Vaccine as Simulated Rabies Post-Exposure Prophylaxis in Adult and Pediatric Population in Thaïland (PHASE3)
- Study of Purified Vero Rabies Vaccine Compared With a Reference Rabies Vaccine as Simulated Rabies Post-Exposure Prophylaxis in Adults in Thaïland (PHASE3)
- Study of Purified Vero Rabies Vaccine Compared With Two Reference Rabies Vaccines in a Simulated Post-Exposure Regimen in Adults (PHASE3)
- Dosage-Escalation Study of the Safety and Immunogenicity of a Novel Rabies Vaccine ChAd155-RG vs. the Comparator RABAVERT Vaccine in Healthy Adult Subjects (PHASE1)
- Study of the Transmission-Blocking Vaccine Pfs230D1-EPA/Matrix-M Against Malaria in Adults in Mali (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Purified inactivated rabies vaccine CI brief — competitive landscape report
- Purified inactivated rabies vaccine updates RSS · CI watch RSS
- Sanofi Pasteur, a Sanofi Company portfolio CI
Frequently asked questions about Purified inactivated rabies vaccine
What is Purified inactivated rabies vaccine?
How does Purified inactivated rabies vaccine work?
What is Purified inactivated rabies vaccine used for?
Who makes Purified inactivated rabies vaccine?
Is Purified inactivated rabies vaccine also known as anything else?
What drug class is Purified inactivated rabies vaccine in?
What development phase is Purified inactivated rabies vaccine in?
What are the side effects of Purified inactivated rabies vaccine?
Related
- Drug class: All Vaccine drugs
- Manufacturer: Sanofi Pasteur, a Sanofi Company — full pipeline
- Therapeutic area: All drugs in Immunology / Infectious Disease
- Indication: Drugs for Rabies post-exposure prophylaxis
- Indication: Drugs for Rabies pre-exposure prophylaxis in high-risk individuals
- Also known as: Verorab®, Verorab
- Compare: Purified inactivated rabies vaccine vs similar drugs
- Pricing: Purified inactivated rabies vaccine cost, discount & access