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Purified Cortophin Gel 80 U

Massachusetts General Hospital · FDA-approved active Small molecule

Purified Cortophin Gel 80 U is a ACTH analog / corticotropin Small molecule drug developed by Massachusetts General Hospital. It is currently FDA-approved for Acute exacerbations of multiple sclerosis, Infantile spasms (West syndrome), Rheumatoid arthritis.

Purified Cortophin Gel is a repository formulation of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release endogenous corticosteroids.

Purified Cortophin Gel is a repository formulation of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release endogenous corticosteroids. Used for Acute exacerbations of multiple sclerosis, Infantile spasms (West syndrome), Rheumatoid arthritis.

At a glance

Generic namePurified Cortophin Gel 80 U
SponsorMassachusetts General Hospital
Drug classACTH analog / corticotropin
TargetMelanocortin-2 receptor (MC2R)
ModalitySmall molecule
Therapeutic areaImmunology / Rheumatology
PhaseFDA-approved

Mechanism of action

ACTH binds to melanocortin-2 receptors on adrenocortical cells, triggering the synthesis and secretion of cortisol and other adrenal steroids. The gel formulation provides sustained, depot-like release of ACTH, allowing for prolonged stimulation of endogenous steroid production rather than direct exogenous steroid administration. This endogenous approach may offer immunomodulatory benefits in certain inflammatory and autoimmune conditions.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about Purified Cortophin Gel 80 U

What is Purified Cortophin Gel 80 U?

Purified Cortophin Gel 80 U is a ACTH analog / corticotropin drug developed by Massachusetts General Hospital, indicated for Acute exacerbations of multiple sclerosis, Infantile spasms (West syndrome), Rheumatoid arthritis.

How does Purified Cortophin Gel 80 U work?

Purified Cortophin Gel is a repository formulation of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release endogenous corticosteroids.

What is Purified Cortophin Gel 80 U used for?

Purified Cortophin Gel 80 U is indicated for Acute exacerbations of multiple sclerosis, Infantile spasms (West syndrome), Rheumatoid arthritis, Systemic lupus erythematosus.

Who makes Purified Cortophin Gel 80 U?

Purified Cortophin Gel 80 U is developed and marketed by Massachusetts General Hospital (see full Massachusetts General Hospital pipeline at /company/massachusetts-general-hospital).

What drug class is Purified Cortophin Gel 80 U in?

Purified Cortophin Gel 80 U belongs to the ACTH analog / corticotropin class. See all ACTH analog / corticotropin drugs at /class/acth-analog-corticotropin.

What development phase is Purified Cortophin Gel 80 U in?

Purified Cortophin Gel 80 U is FDA-approved (marketed).

What are the side effects of Purified Cortophin Gel 80 U?

Common side effects of Purified Cortophin Gel 80 U include Hypertension, Hypokalemia, Hyperglycemia, Insomnia, Mood changes, Acne.

What does Purified Cortophin Gel 80 U target?

Purified Cortophin Gel 80 U targets Melanocortin-2 receptor (MC2R) and is a ACTH analog / corticotropin.

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