{"id":"purified-cortophin-gel-80-u","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Fluid retention"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ACTH binds to melanocortin-2 receptors on adrenocortical cells, triggering the synthesis and secretion of cortisol and other adrenal steroids. The gel formulation provides sustained, depot-like release of ACTH, allowing for prolonged stimulation of endogenous steroid production rather than direct exogenous steroid administration. This endogenous approach may offer immunomodulatory benefits in certain inflammatory and autoimmune conditions.","oneSentence":"Purified Cortophin Gel is a repository formulation of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release endogenous corticosteroids.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:36:46.275Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute exacerbations of multiple sclerosis"},{"name":"Infantile spasms (West syndrome)"},{"name":"Rheumatoid arthritis"},{"name":"Systemic lupus erythematosus"}]},"trialDetails":[{"nctId":"NCT07346079","phase":"PHASE4","title":"Purified Cortrophin® Gel Efficacy and Safety Study of 2 Dose Levels in Patients With Acute Gout Flares","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-12-20","conditions":"Gout Arthritis, Gout Flare, Gout","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Purified Cortophin Gel 80 U","genericName":"Purified Cortophin Gel 80 U","companyName":"Massachusetts General Hospital","companyId":"massachusetts-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Purified Cortophin Gel is a repository formulation of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release endogenous corticosteroids. Used for Acute exacerbations of multiple sclerosis, Infantile spasms (West syndrome), Rheumatoid arthritis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}