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Purified Cortophin Gel, 40 U

Massachusetts General Hospital · FDA-approved active Small molecule

Purified Cortophin Gel, 40 U is a ACTH analog / corticotropin Small molecule drug developed by Massachusetts General Hospital. It is currently FDA-approved for Infantile spasms (West syndrome), Multiple sclerosis relapse, Acute exacerbations of autoimmune and inflammatory conditions.

Purified Cortophin Gel is a repository formulation of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release corticosteroids.

Purified Cortophin Gel is a repository formulation of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release corticosteroids. Used for Infantile spasms (West syndrome), Multiple sclerosis relapse, Acute exacerbations of autoimmune and inflammatory conditions.

At a glance

Generic namePurified Cortophin Gel, 40 U
SponsorMassachusetts General Hospital
Drug classACTH analog / corticotropin
TargetMelanocortin-2 receptor (MC2R)
ModalitySmall molecule
Therapeutic areaImmunology / Rheumatology / Neurology
PhaseFDA-approved

Mechanism of action

ACTH binds to melanocortin-2 receptors on adrenocortical cells, triggering the synthesis and secretion of endogenous glucocorticoids and mineralocorticoids. The gel formulation provides sustained, depot-like release of ACTH, allowing for prolonged stimulation of adrenal hormone production. This endogenous steroid production can provide anti-inflammatory and immunosuppressive effects in various conditions.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about Purified Cortophin Gel, 40 U

What is Purified Cortophin Gel, 40 U?

Purified Cortophin Gel, 40 U is a ACTH analog / corticotropin drug developed by Massachusetts General Hospital, indicated for Infantile spasms (West syndrome), Multiple sclerosis relapse, Acute exacerbations of autoimmune and inflammatory conditions.

How does Purified Cortophin Gel, 40 U work?

Purified Cortophin Gel is a repository formulation of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release corticosteroids.

What is Purified Cortophin Gel, 40 U used for?

Purified Cortophin Gel, 40 U is indicated for Infantile spasms (West syndrome), Multiple sclerosis relapse, Acute exacerbations of autoimmune and inflammatory conditions.

Who makes Purified Cortophin Gel, 40 U?

Purified Cortophin Gel, 40 U is developed and marketed by Massachusetts General Hospital (see full Massachusetts General Hospital pipeline at /company/massachusetts-general-hospital).

What drug class is Purified Cortophin Gel, 40 U in?

Purified Cortophin Gel, 40 U belongs to the ACTH analog / corticotropin class. See all ACTH analog / corticotropin drugs at /class/acth-analog-corticotropin.

What development phase is Purified Cortophin Gel, 40 U in?

Purified Cortophin Gel, 40 U is FDA-approved (marketed).

What are the side effects of Purified Cortophin Gel, 40 U?

Common side effects of Purified Cortophin Gel, 40 U include Hypertension, Hypokalemia, Hyperglycemia, Mood changes / psychiatric effects, Insomnia, Increased infection risk.

What does Purified Cortophin Gel, 40 U target?

Purified Cortophin Gel, 40 U targets Melanocortin-2 receptor (MC2R) and is a ACTH analog / corticotropin.

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