{"id":"purified-cortophin-gel-40-u","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Mood changes / psychiatric effects"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Increased infection risk"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ACTH binds to melanocortin-2 receptors on adrenocortical cells, triggering the synthesis and secretion of endogenous glucocorticoids and mineralocorticoids. The gel formulation provides sustained, depot-like release of ACTH, allowing for prolonged stimulation of adrenal hormone production. This endogenous steroid production can provide anti-inflammatory and immunosuppressive effects in various conditions.","oneSentence":"Purified Cortophin Gel is a repository formulation of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release corticosteroids.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:36:49.681Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infantile spasms (West syndrome)"},{"name":"Multiple sclerosis relapse"},{"name":"Acute exacerbations of autoimmune and inflammatory conditions"}]},"trialDetails":[{"nctId":"NCT07346079","phase":"PHASE4","title":"Purified Cortrophin® Gel Efficacy and Safety Study of 2 Dose Levels in Patients With Acute Gout Flares","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-12-20","conditions":"Gout Arthritis, Gout Flare, Gout","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Purified Cortophin Gel, 40 U","genericName":"Purified Cortophin Gel, 40 U","companyName":"Massachusetts General Hospital","companyId":"massachusetts-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Purified Cortophin Gel is a repository formulation of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release corticosteroids. Used for Infantile spasms (West syndrome), Multiple sclerosis relapse, Acute exacerbations of autoimmune and inflammatory conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}