Last reviewed · How we verify
Purethal Birch immunotherapy
Purethal Birch is an allergen immunotherapy that desensitizes the immune system to birch pollen allergens through gradual exposure.
Purethal Birch is an allergen immunotherapy that desensitizes the immune system to birch pollen allergens through gradual exposure. Used for Birch pollen-induced allergic rhinitis and/or allergic asthma.
At a glance
| Generic name | Purethal Birch immunotherapy |
|---|---|
| Also known as | allergen specific immunotherapy |
| Sponsor | Medical University of Silesia |
| Drug class | Allergen immunotherapy |
| Modality | Small molecule |
| Therapeutic area | Immunology / Allergy |
| Phase | Phase 3 |
Mechanism of action
This immunotherapy works by administering increasing doses of birch pollen allergen extract to induce immune tolerance and shift the immune response from IgE-mediated (allergic) to IgG-mediated (protective) antibodies. Over time, this reduces allergic symptoms and the need for symptomatic medications in patients with birch pollen allergy.
Approved indications
- Birch pollen-induced allergic rhinitis and/or allergic asthma
Common side effects
- Local injection site reactions (itching, swelling, erythema)
- Oral allergy syndrome
- Systemic allergic reactions
Key clinical trials
- Efficacy and Safety of Birch Pollen Immunotherapy in Local Allergic Rhinitis (PHASE3)
- PURETHAL Birch RUSH Study (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |