{"id":"purethal-birch-immunotherapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (itching, swelling, erythema)"},{"rate":null,"effect":"Oral allergy syndrome"},{"rate":null,"effect":"Systemic allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL4650246","moleculeType":"Small molecule"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"This immunotherapy works by administering increasing doses of birch pollen allergen extract to induce immune tolerance and shift the immune response from IgE-mediated (allergic) to IgG-mediated (protective) antibodies. Over time, this reduces allergic symptoms and the need for symptomatic medications in patients with birch pollen allergy.","oneSentence":"Purethal Birch is an allergen immunotherapy that desensitizes the immune system to birch pollen allergens through gradual exposure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:30:41.511Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Birch pollen-induced allergic rhinitis and/or allergic asthma"}]},"trialDetails":[{"nctId":"NCT03157505","phase":"PHASE3","title":"Efficacy and Safety of Birch Pollen Immunotherapy in Local Allergic Rhinitis","status":"COMPLETED","sponsor":"Medical University of Silesia","startDate":"2014-01-05","conditions":"Allergic Rhinitis, Allergic Reaction","enrollment":78},{"nctId":"NCT01918956","phase":"PHASE4","title":"PURETHAL Birch RUSH Study","status":"COMPLETED","sponsor":"HAL Allergy","startDate":"2013-09","conditions":"Allergic Rhinitis, Allergic Rhinoconjunctivitis","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["allergen specific immunotherapy"],"phase":"phase_3","status":"active","brandName":"Purethal Birch immunotherapy","genericName":"Purethal Birch immunotherapy","companyName":"Medical University of Silesia","companyId":"medical-university-of-silesia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Purethal Birch immunotherapy is used to treat conditions such as Allergic Rhinitis, Allergic Reaction, and Allergic Rhinoconjunctivitis. The mechanism of Purethal Birch immunotherapy is unknown, as it is classified as a small molecule with no specified mechanism of action.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}