Last reviewed · How we verify
Punctum Plug
Punctum Plug is a biodegradable collagen shield used to treat punctal occlusion.
Punctum Plug is a biodegradable collagen shield used to treat punctal occlusion. Used for Treatment of dry eye disease.
At a glance
| Generic name | Punctum Plug |
|---|---|
| Sponsor | Ocular Therapeutix, Inc. |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
Punctum Plug works by physically blocking the tear ducts to reduce tear drainage and alleviate dry eye symptoms. This is achieved through the insertion of a biodegradable collagen shield into the tear duct, which gradually dissolves over time.
Approved indications
- Treatment of dry eye disease
Common side effects
- Discomfort
- Inflammation
Key clinical trials
- A Study of Nipocalimab in Adults With Primary Sjogren's Syndrome (pSS) (PHASE2)
- Punctal Plugs and Iodine Related Discomfort (NA)
- Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B (PHASE1)
- Quality of Life Improvement in Dry Eye Patients After Intense Pulsed Light Therapy Compared to Punctal Plugs (NA)
- Phase II Study Evaluating Safety/Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery (PHASE2)
- An Open-Label, Multi-Center, Clinical Study Evaluating the Effect of the NDE L68 StableFit® Punctal Plug on the Tear Lake (NA)
- Phase 3 Study Evaluating Safety and Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery (PHASE3)
- Outcome of Omega 3 FA and Punctal Plugs on Ocular Surface Disease (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Punctum Plug CI brief — competitive landscape report
- Punctum Plug updates RSS · CI watch RSS
- Ocular Therapeutix, Inc. portfolio CI