{"id":"punctum-plug","safety":{"commonSideEffects":[{"rate":null,"effect":"Discomfort"},{"rate":null,"effect":"Inflammation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Punctum Plug works by physically blocking the tear ducts to reduce tear drainage and alleviate dry eye symptoms. This is achieved through the insertion of a biodegradable collagen shield into the tear duct, which gradually dissolves over time.","oneSentence":"Punctum Plug is a biodegradable collagen shield used to treat punctal occlusion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:30:47.219Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of dry eye disease"}]},"trialDetails":[{"nctId":"NCT04968912","phase":"PHASE2","title":"A Study of Nipocalimab in Adults With Primary Sjogren's Syndrome (pSS)","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2021-09-21","conditions":"Sjogren's Syndrome","enrollment":163},{"nctId":"NCT03396809","phase":"NA","title":"Punctal Plugs and Iodine Related Discomfort","status":"WITHDRAWN","sponsor":"University of New Mexico","startDate":"2017-07-26","conditions":"Dry Eye Syndromes","enrollment":""},{"nctId":"NCT05618730","phase":"PHASE1","title":"Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B","status":"UNKNOWN","sponsor":"Eximore Ltd.","startDate":"2022-09-29","conditions":"Dry Eye, Keratoconjunctivitis Sicca, Ocular Inflammation","enrollment":20},{"nctId":"NCT05331924","phase":"NA","title":"Quality of Life Improvement in Dry Eye Patients After Intense Pulsed Light Therapy Compared to Punctal Plugs","status":"COMPLETED","sponsor":"Tanta University","startDate":"2020-12-01","conditions":"Evaporative Dry Eye","enrollment":30},{"nctId":"NCT01666210","phase":"PHASE2","title":"Phase II Study Evaluating Safety/Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery","status":"COMPLETED","sponsor":"Ocular Therapeutix, Inc.","startDate":"2012-10","conditions":"Ocular Inflammation and Pain","enrollment":60},{"nctId":"NCT04280653","phase":"NA","title":"An Open-Label, Multi-Center, Clinical Study Evaluating the Effect of the NDE L68 StableFit® Punctal Plug on the Tear Lake","status":"COMPLETED","sponsor":"Mati Therapeutics Inc.","startDate":"2019-08-28","conditions":"Dry Eye Syndromes","enrollment":15},{"nctId":"NCT02034019","phase":"PHASE3","title":"Phase 3 Study Evaluating Safety and Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery","status":"COMPLETED","sponsor":"Ocular Therapeutix, Inc.","startDate":"2014-02","conditions":"Post Ocular Surgical Inflammation and Pain","enrollment":247},{"nctId":"NCT03686059","phase":"PHASE4","title":"Outcome of Omega 3 FA and Punctal Plugs on Ocular Surface Disease","status":"COMPLETED","sponsor":"Benha University","startDate":"2018-07-02","conditions":"Ocular Surface Disease","enrollment":90},{"nctId":"NCT03318146","phase":"NA","title":"Safety, Tolerability and Preliminary Efficacy of Unilateral Latanoprost-loaded Punctual Plug -EXP-LP","status":"UNKNOWN","sponsor":"Shaare Zedek Medical Center","startDate":"2018-06-01","conditions":"Glaucoma, Ocular Hypertension, IOP","enrollment":40},{"nctId":"NCT02014142","phase":"PHASE2","title":"A Phase 2 Single-Masked, Randomized Study of Latanoprost PPDS in Ocular Hypertension or Open-Angle Glaucoma","status":"COMPLETED","sponsor":"Mati Therapeutics Inc.","startDate":"2013-12","conditions":"Ocular Hypertension, Open-Angle Glaucoma","enrollment":86},{"nctId":"NCT02312544","phase":"PHASE2","title":"Phase 2b Study Evaluating Safety and Efficacy of OTX-TP Compared to Timolol Drops in the Treatment of Subjects With Open Angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Ocular Therapeutix, Inc.","startDate":"2014-11","conditions":"Glaucoma, Ocular Hypertension","enrollment":72},{"nctId":"NCT01845038","phase":"PHASE1","title":"Multi-Arm Feasibility Study Evaluating OTX-TP Compared to Timolol in Treatment of Subjects With Open Angle Glaucoma","status":"COMPLETED","sponsor":"Ocular Therapeutix, Inc.","startDate":"2013-04","conditions":"Glaucoma","enrollment":41},{"nctId":"NCT01800175","phase":"PHASE1","title":"Non-Significant Risk Feasibility Study to Assess Retention and Replacement of the OTX Punctum Plug","status":"UNKNOWN","sponsor":"Ocular Therapeutix, Inc.","startDate":"2013-02","conditions":"Healthy Subjects","enrollment":60},{"nctId":"NCT00650702","phase":"PHASE2","title":"Safety and Efficacy of Punctum Plug Delivery System in Subjects With Open-Angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Mati Therapeutics Inc.","startDate":"2008-03","conditions":"Glaucoma, Ocular Hypertension","enrollment":36},{"nctId":"NCT00735865","phase":"NA","title":"Lid Margin And Conjunctival Microbial Flora Following Punctum Occlusion","status":"COMPLETED","sponsor":"Lahey Clinic","startDate":"2003-07","conditions":"Dry Eye Syndrome","enrollment":55}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":25,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Punctum Plug","genericName":"Punctum Plug","companyName":"Ocular Therapeutix, Inc.","companyId":"ocular-therapeutix-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Punctum Plug is a biodegradable collagen shield used to treat punctal occlusion. Used for Treatment of dry eye disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}