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PTH/Calcium
This combination therapy works by supplementing parathyroid hormone (PTH) to regulate calcium homeostasis and bone metabolism.
This combination therapy works by supplementing parathyroid hormone (PTH) to regulate calcium homeostasis and bone metabolism. Used for Hypoparathyroidism, Post-surgical hypoparathyroidism.
At a glance
| Generic name | PTH/Calcium |
|---|---|
| Also known as | PREOS |
| Sponsor | Shire |
| Drug class | Hormone replacement / Mineral supplement combination |
| Target | PTH receptor (PTH1R) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology |
| Phase | Phase 3 |
Mechanism of action
PTH is an endocrine hormone that increases serum calcium levels by stimulating osteoclast-mediated bone resorption, enhancing renal calcium reabsorption, and promoting active vitamin D synthesis. The addition of calcium supplementation supports the PTH mechanism by providing substrate for bone mineralization and maintaining serum calcium levels. Together, these agents address hypocalcemia and related mineral metabolism disorders.
Approved indications
- Hypoparathyroidism
- Post-surgical hypoparathyroidism
Common side effects
- Hypercalcemia
- Hyperphosphatemia
- Injection site reactions
- Nausea
Key clinical trials
- Natural History Study of Parathyroid Disorders
- PRESS -PAR: Early Detection and PREvention of Symptomatic postSurgical hypoPARathyroidism After Thyroid Surgery" (NA)
- Thyroidectomy: Microscopic Versus Conventional (NA)
- Parathyroid Allotransplant for Treatment of Hypoparathyroidism (PHASE1, PHASE2)
- Comparing PTeye-assisted Versus Conventional Total Thyroidectomy (NA)
- Parathyroidectomy After Kidney Transplantation (NA)
- Aldosterone Variations in Patients With Primary Hyperparathyroidism After Surgery
- Effects of Total Thyroid Removal on Parathyroid Function and Quality of Life (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- PTH/Calcium CI brief — competitive landscape report
- PTH/Calcium updates RSS · CI watch RSS
- Shire portfolio CI