{"id":"pth-calcium","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Hyperphosphatemia"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL1200668","moleculeType":"Small molecule","molecularWeight":"110.98"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PTH is an endocrine hormone that increases serum calcium levels by stimulating osteoclast-mediated bone resorption, enhancing renal calcium reabsorption, and promoting active vitamin D synthesis. The addition of calcium supplementation supports the PTH mechanism by providing substrate for bone mineralization and maintaining serum calcium levels. Together, these agents address hypocalcemia and related mineral metabolism disorders.","oneSentence":"This combination therapy works by supplementing parathyroid hormone (PTH) to regulate calcium homeostasis and bone metabolism.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:30:41.884Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypoparathyroidism"},{"name":"Post-surgical hypoparathyroidism"}]},"trialDetails":[{"nctId":"NCT04969926","phase":"","title":"Natural History Study of Parathyroid Disorders","status":"RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2021-11-30","conditions":"Parathyroid Cancer, Primary Hyperparathyroidism, Pseudohypoparathyroidism","enrollment":3000},{"nctId":"NCT07491601","phase":"NA","title":"PRESS -PAR: Early Detection and PREvention of Symptomatic postSurgical hypoPARathyroidism After Thyroid Surgery\"","status":"RECRUITING","sponsor":"Nicolas Schlegel","startDate":"2025-01-08","conditions":"Postoperative Hypoparathyroidism, Postsurgical Hypoparathyroidism, Hypoparathyroidism Post-surgical","enrollment":336},{"nctId":"NCT07488858","phase":"NA","title":"Thyroidectomy: Microscopic Versus Conventional","status":"COMPLETED","sponsor":"Shahida Islam Medical Complex","startDate":"2025-12-16","conditions":"Thyroid Cancer, Thyroid Surgeries","enrollment":74},{"nctId":"NCT06961071","phase":"PHASE1, PHASE2","title":"Parathyroid Allotransplant for Treatment of Hypoparathyroidism","status":"RECRUITING","sponsor":"Peter Stock","startDate":"2026-01-15","conditions":"Hypoparathyroidism, Hypoparathyroidism Postprocedural, Hypoparathyroidism Post-surgical","enrollment":3},{"nctId":"NCT07416149","phase":"NA","title":"Comparing PTeye-assisted Versus Conventional Total Thyroidectomy","status":"RECRUITING","sponsor":"The University of Hong Kong","startDate":"2025-09-16","conditions":"Hypocalcemia, Parathyroid, Hypoparathyroidism Post-surgical","enrollment":210},{"nctId":"NCT07415421","phase":"NA","title":"Parathyroidectomy After Kidney Transplantation","status":"RECRUITING","sponsor":"Aarhus University Hospital","startDate":"2026-01-20","conditions":"Hyperparathyroidism, Kidney Transplantation Recipients","enrollment":85},{"nctId":"NCT07388914","phase":"","title":"Aldosterone Variations in Patients With Primary Hyperparathyroidism After Surgery","status":"NOT_YET_RECRUITING","sponsor":"Central Hospital, Nancy, France","startDate":"2026-02-01","conditions":"Primary Hyperparathyroidism, Primary Hyperparathyroidism Due to Adenoma","enrollment":400},{"nctId":"NCT07381998","phase":"NA","title":"Effects of Total Thyroid Removal on Parathyroid Function and Quality of Life","status":"ENROLLING_BY_INVITATION","sponsor":"Aarhus University Hospital","startDate":"2026-01-01","conditions":"Hypoparathyroidism Post-surgical, Quality of Life","enrollment":150},{"nctId":"NCT07299838","phase":"","title":"Palopegteriparatide in Chronic Hypoparathyroidism","status":"COMPLETED","sponsor":"National and Kapodistrian University of Athens","startDate":"2024-06-01","conditions":"Hypoparathyroidism","enrollment":90},{"nctId":"NCT07193056","phase":"","title":"The CPH-MBD Cohort","status":"NOT_YET_RECRUITING","sponsor":"Herlev Hospital","startDate":"2025-12","conditions":"Chronic Kidney Disease Mineral and Bone Disorder, Chronic Kidney Disease (CKD), Bone Markers","enrollment":1000},{"nctId":"NCT05029128","phase":"NA","title":"Enhancing Skeletal Adaptations to PTH and Exercise","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2023-01-01","conditions":"Exercise, Bone Resorption, Bone Formation","enrollment":18},{"nctId":"NCT07242612","phase":"NA","title":"Bone Turnover Markers and Treatment Efficacy in Postmenopausal Osteoporosis","status":"RECRUITING","sponsor":"Khyber Medical University Peshawar","startDate":"2025-10-01","conditions":"Osteoporosis, Osteoporosis, Postmenopausal","enrollment":40},{"nctId":"NCT01922440","phase":"","title":"A Registry for Participants With Chronic Hypoparathyroidism","status":"ACTIVE_NOT_RECRUITING","sponsor":"Takeda","startDate":"2013-07-30","conditions":"Hypoparathyroidism","enrollment":1339},{"nctId":"NCT07160348","phase":"","title":"Translation and Validation of the Hypoparathyroidism Patient Experience Scales (HPES) Questionnaire in Greek","status":"NOT_YET_RECRUITING","sponsor":"Aristotle University Of Thessaloniki","startDate":"2025-10-01","conditions":"Hypoparathyroidism","enrollment":200},{"nctId":"NCT02580604","phase":"NA","title":"PTH And Calcium Responses to Exercise in Older Adults Experiment 2 (PACE Sr. 2)","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2015-11","conditions":"Osteoporosis","enrollment":12},{"nctId":"NCT03994172","phase":"PHASE4","title":"Novel Combination Therapy for Osteoporosis in Men","status":"ACTIVE_NOT_RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2019-07-01","conditions":"Male Osteoporosis","enrollment":40},{"nctId":"NCT07083531","phase":"","title":"Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait","status":"RECRUITING","sponsor":"UConn Health","startDate":"2022-08-23","conditions":"Sickle Cell Disease, Sickle Cell Trait","enrollment":50},{"nctId":"NCT07043010","phase":"NA","title":"WHITE CAP: Intra-operative Parathyroid Tissue Sensor (PTS)-Guided Assessment of Parathyroid Viability and Surgical Decision-Making","status":"NOT_YET_RECRUITING","sponsor":"Fujian Medical University","startDate":"2025-07-01","conditions":"Hyperparathyroidism, Primary, Parathyroid Neoplasms, Parathyroid Adenoma","enrollment":120},{"nctId":"NCT05151484","phase":"PHASE4","title":"Novel Precision Medicine Approach to Treatment of Osteoporosis Based on Bone Turnover","status":"RECRUITING","sponsor":"Madhumathi Rao","startDate":"2022-03-21","conditions":"Age-Related Osteoporosis","enrollment":60},{"nctId":"NCT06901102","phase":"PHASE1, PHASE2","title":"Effect of Bee Venom on Chronic Kidney Disease-Mineral Bone Disorders in Hemodialysis Patients: a Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Mansoura University","startDate":"2025-04-10","conditions":"Chronic Kidney Disease, Bee Venom, Hemodialysis","enrollment":60},{"nctId":"NCT05252884","phase":"NA","title":"Calcium+Calcitriol Versus PTH for the Prevention of Hypocalcemia in Thyroidectomy. Randomized Clinical Trial","status":"COMPLETED","sponsor":"Centro de Excelencia en Enfermedades de Cabeza y Cuello","startDate":"2022-06-30","conditions":"Thyroid Cancer, Goiter, Thyroiditis","enrollment":258},{"nctId":"NCT03133195","phase":"PHASE3","title":"The Effect of Teriparatide on Bone Union in Unstable Intertrochanteric Fracture Patients Treated With PFNA","status":"COMPLETED","sponsor":"King Chulalongkorn Memorial Hospital","startDate":"2017-05-17","conditions":"Unstable Intertrochanteric Fracture, Pertrochanteric Fracture of Femur, Closed","enrollment":50},{"nctId":"NCT06274970","phase":"NA","title":"PaThERAS: ERAS Protocols in Thyroid & Parathyroid Surgery","status":"COMPLETED","sponsor":"Sanjay Gandhi Postgraduate Institute of Medical Sciences","startDate":"2023-01-25","conditions":"Thyroid Diseases, Parathyroid Diseases, ERAS","enrollment":96},{"nctId":"NCT04509011","phase":"NA","title":"Autofluorescence vs Clinical Assessment of Parathyroid Glands During Thyroid Surgery","status":"COMPLETED","sponsor":"Region Skane","startDate":"2021-01-05","conditions":"Hypoparathyroidism Postprocedural","enrollment":516},{"nctId":"NCT05642741","phase":"","title":"Validation of a Hypoparathyroidism Self-questionnaire","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2023-05-02","conditions":"Thyroidectomy, Hypoparathyroidism Postprocedural","enrollment":81},{"nctId":"NCT03935984","phase":"PHASE4","title":"Calcitonin Pre-treatment to Improve SPECT-CT Sensitivity","status":"RECRUITING","sponsor":"Joseph Sferra","startDate":"2019-05-29","conditions":"Primary Hyperparathyroidism, Hypercalcemia","enrollment":37},{"nctId":"NCT05313477","phase":"PHASE4","title":"The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With TDF","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2022-05-01","conditions":"Parathyroid Hormone, Tenofovir Disoproxil Fumarate, Chronic Hepatitis B Virus","enrollment":64},{"nctId":"NCT03249012","phase":"NA","title":"Quality of Life Related to Different Treatment Protocols for Post-thyroidectomy Hypoparathyroidism","status":"RECRUITING","sponsor":"CHU de Quebec-Universite Laval","startDate":"2017-09-01","conditions":"Hypoparathyroidism Postprocedural, Quality of Life","enrollment":120},{"nctId":"NCT06499246","phase":"NA","title":"Parathyroid Allotransplant for Severe Refractory Hypoparathyroidism","status":"RECRUITING","sponsor":"Karen Devon","startDate":"2024-07","conditions":"Hypoparathyroidism Postprocedural","enrollment":5},{"nctId":"NCT06495385","phase":"","title":"Evaluation of a Multidisciplinary Care Pathway on the Evolution of Renal Function in Patients With Advanced Chronic Kidney Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"Centre Hospitalier Universitaire de Saint Etienne","startDate":"2024-04-09","conditions":"Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5","enrollment":535},{"nctId":"NCT03123406","phase":"PHASE4","title":"Efficacy and Safety of Cinacalcet in Ca, P and iPTH Levels in Patients With Mild, Moderate and Severe SHPT","status":"COMPLETED","sponsor":"Kyowa Kirin China Pharmaceutical Co., Ltd.","startDate":"2017-04-19","conditions":"Hyperparathyroidism; Secondary, Renal","enrollment":750},{"nctId":"NCT06383117","phase":"NA","title":"Understanding Effects of Calcium on the Gut-Bone Axis","status":"COMPLETED","sponsor":"University of Georgia","startDate":"2023-10-17","conditions":"Healthy, Adult, Calcium","enrollment":14},{"nctId":"NCT03659500","phase":"","title":"Clinical Outcomes and Costs of 4-Week Versus 6-Week Bloodwork for Patients on Hemodialysis","status":"COMPLETED","sponsor":"Samuel Silver","startDate":"2012-06-01","conditions":"End Stage Renal Disease","enrollment":400},{"nctId":"NCT05264610","phase":"","title":"Retrospective Analysis of the Effects of Perioperative Osteoanabolic Treatment on Patients With Spinal (Fusion) Surgery.","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2021-07-20","conditions":"Spinal (Fusion) Surgery","enrollment":40},{"nctId":"NCT05171153","phase":"","title":"Analysis of Bone Quality in Adult Patients With Inflammatory Bowel Disease","status":"COMPLETED","sponsor":"Quironsalud","startDate":"2021-10-01","conditions":"Inflammatory Bowel Diseases, Osteoporosis","enrollment":100},{"nctId":"NCT06077708","phase":"NA","title":"Diabetes Mellitus and Periodontitis and Vitamin D Supplementation","status":"COMPLETED","sponsor":"Kırıkkale University","startDate":"2022-08-23","conditions":"Diabetes Mellitus Type 2 With Periodontal Disease","enrollment":38},{"nctId":"NCT04694976","phase":"","title":"Vitamin D Status in Children With Sickle Cell Disease Living in Lyon, France","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2021-02-04","conditions":"Vitamin D Deficiency, Sickle Cell Disease","enrollment":130},{"nctId":"NCT03324880","phase":"PHASE4","title":"A Study to Learn if Recombinant Human Parathyroid Hormone [rhPTH(1-84)] Can Improve Symptoms and Metabolic Control in Adults With Hypoparathyroidism (BALANCE)","status":"COMPLETED","sponsor":"Shire","startDate":"2018-01-24","conditions":"Hypoparathyroidism","enrollment":93},{"nctId":"NCT03958409","phase":"NA","title":"Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients","status":"COMPLETED","sponsor":"Yale University","startDate":"2018-12-12","conditions":"Skeletal Anomalies, Kidney Transplant; Complications","enrollment":8},{"nctId":"NCT05275491","phase":"","title":"Fibroblast Growth Factor 23 and Sclerostin in Relation to Calcium in COVID-19 Patients","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2022-05-01","conditions":"COVID-19","enrollment":66},{"nctId":"NCT05688007","phase":"","title":"The Association Between Parathyroid Hormone and Preterm Labor","status":"COMPLETED","sponsor":"Ain Shams Maternity Hospital","startDate":"2021-04-01","conditions":"Preterm Labor, Parathyroid Diseases","enrollment":100},{"nctId":"NCT05352880","phase":"NA","title":"Hypomagnesemia and Its Association With Calcineurin Inhibitors Use in Renal Transplant Recipients","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2022-05-10","conditions":"Renal Transplantation; Complication","enrollment":80},{"nctId":"NCT04059380","phase":"","title":"Evaluation of iMmune Function in Post-surgical and AuToimmune HYpoparathyroidism (EMPATHY)","status":"COMPLETED","sponsor":"University of Roma La Sapienza","startDate":"2019-05-13","conditions":"Hypoparathyroidism, Hypoparathyroidism Postprocedural, Hypoparathyroidism Due to Impaired Parathormone Secretion","enrollment":40},{"nctId":"NCT04750460","phase":"PHASE3","title":"Injection of Teriparatide to Prevent Hypocalcemia After Parathyroidectomy in Dialysis Patients (TeriCa).","status":"COMPLETED","sponsor":"Saint Petersburg State University, Russia","startDate":"2021-03-01","conditions":"Secondary Hyperparathyroidism, Chronic Kidney Disease-Mineral and Bone Disorder, Dialysis","enrollment":20},{"nctId":"NCT00345839","phase":"PHASE3","title":"E.V.O.L.V.E. Trial™: EValuation Of Cinacalcet Hydrochloride (HCl) Therapy to Lower CardioVascular Events","status":"COMPLETED","sponsor":"Amgen","startDate":"2006-08-22","conditions":"Secondary Hyperparathyroidism, Chronic Kidney Disease","enrollment":3883},{"nctId":"NCT05430932","phase":"NA","title":"Effect Of Laparoscopic Sleeve Gastrectomy on Vitamin D, Parathormone and Calcium Levels","status":"COMPLETED","sponsor":"Kafrelsheikh University","startDate":"2018-10-01","conditions":"Bariatric Surgery Candidate, Obesity, Morbid, Vitamin D Deficiency","enrollment":40},{"nctId":"NCT05451472","phase":"NA","title":"Evluation of Thyroid Functions in Hemodialysis Childern in Sohag University Hospital","status":"UNKNOWN","sponsor":"Sohag University","startDate":"2022-07-01","conditions":"Chronic Renal Failure","enrollment":39},{"nctId":"NCT04931602","phase":"","title":"Determining Feasibility of a Model of Care for Secondary Fracture Prevention","status":"UNKNOWN","sponsor":"Aga Khan University","startDate":"2021-07-01","conditions":"Osteoporosis","enrollment":172},{"nctId":"NCT04727281","phase":"NA","title":"Dialysis Recovery Time: Associated Factors and Its Relation to Quality of Life","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2021-02-01","conditions":"Dialysis; Complications","enrollment":210},{"nctId":"NCT00576836","phase":"PHASE2","title":"Thymus Transplantation Dose in DiGeorge #932","status":"COMPLETED","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"2004-09-02","conditions":"DiGeorge Anomaly, DiGeorge Syndrome, Complete DiGeorge Anomaly","enrollment":7},{"nctId":"NCT00579527","phase":"PHASE1, PHASE2","title":"Phase I/II Thymus Transplantation With Immunosuppression #950","status":"COMPLETED","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"2005-12-19","conditions":"DiGeorge Anomaly, Complete DiGeorge Anomaly, Complete Atypical DiGeorge Anomaly","enrollment":14},{"nctId":"NCT04916743","phase":"NA","title":"The Effect of Exercise on Blood Parameters Related to Dialysis Patients' Survival","status":"COMPLETED","sponsor":"Pardis Specialized Wellness Institute","startDate":"2021-07-30","conditions":"Chronic Kidney Diseases, End Stage Renal Disease, Hemodialysis","enrollment":44},{"nctId":"NCT05281107","phase":"EARLY_PHASE1","title":"Vitamin D Supplementation and PTH Response Among Malaysian Adults","status":"COMPLETED","sponsor":"IMU University, Malaysia","startDate":"2015-07-10","conditions":"Healthy","enrollment":106},{"nctId":"NCT02397629","phase":"","title":"Using Serum Parathyroid Hormones and Calcium to Improve Prostate Cancer Diagnosis","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2013-05","conditions":"Prostate Cancer","enrollment":62},{"nctId":"NCT04412694","phase":"PHASE4","title":"The Effect of Preoperative Oral Dexamethasone Supplementation on the Outcome of Thyroidectomised Patients.","status":"UNKNOWN","sponsor":"Medical University of Lodz","startDate":"2020-07-01","conditions":"Hypocalcemia, Vitamin D Deficiency, Postoperative Complications","enrollment":100},{"nctId":"NCT05214872","phase":"","title":"The Impact of Selected Factors on the Cardiovascular System in Chronic Kidney Disease","status":"COMPLETED","sponsor":"Poznan University of Medical Sciences","startDate":"2016-03-25","conditions":"Atherosclerosis of Artery, Inflammation, Chronic Kidney Diseases","enrollment":252},{"nctId":"NCT04814316","phase":"","title":"Effects of Lansoprazole on Bone Turnover Markers","status":"COMPLETED","sponsor":"Ataturk University","startDate":"2019-12-02","conditions":"Bone Turnover Rate Disorder, Calcium Metabolism Disorders","enrollment":60},{"nctId":"NCT02414386","phase":"","title":"Serum Vitamin D Levels in Critically Ill Patients Undergoing Regional Citrate Anticoagulation CRRT","status":"COMPLETED","sponsor":"Uniwersytecki Szpital Kliniczny w Opolu","startDate":"2015-08","conditions":"Multi Organ Failure, Acute Kidney Injury","enrollment":40},{"nctId":"NCT05113628","phase":"NA","title":"Methylene Blue Spray for Identification of Recurrent Laryngeal Nerve and Parathyroid Gland","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2020-01-15","conditions":"Methylene Blue, Recurrent Laryngeal Nerve Injuries, Parathyroid Gland","enrollment":80},{"nctId":"NCT04986319","phase":"","title":"Reference Interval of Vitamin D of Coastal Fishermen in Cox's Bazar District of Bangladesh","status":"COMPLETED","sponsor":"Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders","startDate":"2017-01","conditions":"Vitamin D Deficiency","enrollment":556},{"nctId":"NCT02204579","phase":"PHASE2","title":"A Study to Determine the Effects of NPSP795 on the Calcium-sensing Receptor in Subjects With Autosomal Dominant Hypocalcemia as Measured by PTH Levels and Blood Calcium Concentrations","status":"COMPLETED","sponsor":"Shire","startDate":"2014-07-18","conditions":"Autosomal Dominant Hypocalcemia (ADH)","enrollment":7},{"nctId":"NCT04987450","phase":"","title":"Effect of Glucocorticoids on Inflammation and Bone Metabolism in Patients With Glomerular Disease","status":"UNKNOWN","sponsor":"Medical University of Lodz","startDate":"2018-10-01","conditions":"Glomerular Disease","enrollment":40},{"nctId":"NCT04519034","phase":"","title":"Vitamin D Status and Immune-inflammatory Status in Different UK Populations With COVID-19 Infection","status":"COMPLETED","sponsor":"Guy's and St Thomas' NHS Foundation Trust","startDate":"2020-09-01","conditions":"Covid19","enrollment":27628},{"nctId":"NCT01506947","phase":"PHASE4","title":"A Pilot Clinical Study Evaluating the Effect of Parathyroid Hormone (PTH) Lowering On Erythropoietin Consumption in Calcitriol-Resistant Patients","status":"COMPLETED","sponsor":"AbbVie (prior sponsor, Abbott)","startDate":"2012-05-10","conditions":"Moderate to Severe Secondary Hyperparathyroidism, Stage 5 Chronic Kidney Diseases","enrollment":65},{"nctId":"NCT02910466","phase":"PHASE4","title":"A Study of Extended Use of Recombinant Human Parathyroid Hormone (rhPTH(1-84)) in Hypoparathyroidism","status":"COMPLETED","sponsor":"Shire","startDate":"2016-10-27","conditions":"Chronic Hypoparathyroidism, Hypoparathyroidism","enrollment":39},{"nctId":"NCT02023411","phase":"PHASE2","title":"Efficacy of Teriparatide in Diabetic Inactive Charcot Neuroarthropathy of Foot","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2014-01","conditions":"Diabetic Neuropathic Arthropathy","enrollment":20},{"nctId":"NCT02824718","phase":"PHASE2","title":"Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Severe Primary Hypoparathyroidism","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2017-06-06","conditions":"Autosomal Dominant Hypocalcemia OR Primary Hypoparathyroidism Related to Other Cause But Complicated by Hypercalciuria Under Treatment","enrollment":16},{"nctId":"NCT01679080","phase":"PHASE2","title":"The Effect of Treatment With Teriparatide and Zoledronic Acid in Patients With Osteogenesis Imperfecta","status":"TERMINATED","sponsor":"University of Aarhus","startDate":"2012-11","conditions":"Osteogenesis Imperfecta","enrollment":9},{"nctId":"NCT02781844","phase":"PHASE1","title":"Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Participants With Hypoparathyroidism","status":"COMPLETED","sponsor":"Shire","startDate":"2017-04-03","conditions":"Hypoparathyroidism","enrollment":34},{"nctId":"NCT03027557","phase":"PHASE3","title":"Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet.","status":"COMPLETED","sponsor":"Peter Vestergaard","startDate":"2017-03-01","conditions":"Primary Hyperparathyroidism, Parathyroid Adenoma, Parathyroid Hyperplasia","enrollment":46},{"nctId":"NCT00172172","phase":"PHASE3","title":"Calcium Supplementation in Postmenopausal Women","status":"COMPLETED","sponsor":"Shire","startDate":"2004-01-10","conditions":"Osteoporosis","enrollment":374},{"nctId":"NCT00172081","phase":"PHASE3","title":"TOP: Recombinant Human Parathyroid Hormone (ALX1-11) on Fracture Incidence in Women With Postmenopausal Osteoporosis","status":"COMPLETED","sponsor":"Shire","startDate":"2000-04-27","conditions":"Osteoporosis","enrollment":2532},{"nctId":"NCT03299244","phase":"PHASE3","title":"Head-to-Head Study of Etelcalcetide and Cinacalcet in Asian Hemodialysis Patients With Secondary Hyperparathyroidism (SHPT)","status":"COMPLETED","sponsor":"Amgen","startDate":"2018-05-15","conditions":"Secondary Hyperparathyroidism, Chronic Kidney Disease","enrollment":637},{"nctId":"NCT04783337","phase":"NA","title":"Local Remodelling of Bone Fracture Healing","status":"COMPLETED","sponsor":"Medical University Innsbruck","startDate":"2015-12-10","conditions":"Fracture Healing, Distal Radius Fracture","enrollment":106},{"nctId":"NCT04690842","phase":"","title":"Improving Safety in Pediatric Thyroidectomy by PTH Measurements","status":"COMPLETED","sponsor":"Hospital de Niños R. Gutierrez de Buenos Aires","startDate":"2014-06","conditions":"Hypoparathyroidism Postprocedural","enrollment":66},{"nctId":"NCT04662437","phase":"","title":"The Status of Parathyroid Hormone Secretion in Covid-19 Patients","status":"COMPLETED","sponsor":"Bezmialem Vakif University","startDate":"2020-09-10","conditions":"COVID-19 Infection, Parathyroid Gland, Parathyroid Hormone","enrollment":150},{"nctId":"NCT04558268","phase":"PHASE2, PHASE3","title":"Low Dose Prednisone Therapy in Women With Recurrent Pregnancy Loss","status":"UNKNOWN","sponsor":"Soroka University Medical Center","startDate":"2020-12","conditions":"Recurrent Pregnancy Loss(RPL), Recurrent Miscarriage","enrollment":242},{"nctId":"NCT04523974","phase":"","title":"Preemptive and Precise Intervention for CKD-SHPT","status":"UNKNOWN","sponsor":"Shanghai Zhongshan Hospital","startDate":"2020-10-01","conditions":"Hyperparathyroidism; Secondary, Renal","enrollment":50},{"nctId":"NCT01656629","phase":"NA","title":"Stem Cell Recruitment in Osteoporosis Therapy","status":"TERMINATED","sponsor":"Johns Hopkins University","startDate":"2012-08","conditions":"Low Bone Density","enrollment":55},{"nctId":"NCT03331536","phase":"","title":"Skeletal Health in Bariatric Surgery Patients","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2018-03-22","conditions":"Bariatric Surgery, Osteoporosis, Fractures, Bone","enrollment":27},{"nctId":"NCT01277510","phase":"PHASE3","title":"Pediatric Chronic Kidney Disease Safety and Efficacy","status":"TERMINATED","sponsor":"Amgen","startDate":"2011-06-28","conditions":"Chronic Kidney Disease, Hyperparathyroidism, Hyperparathyroidism, Secondary","enrollment":43},{"nctId":"NCT02341417","phase":"PHASE3","title":"Extension Study of Cinacalcet for Treatment of Secondary Hyperparathyroidism (SHPT) in Pediatric Patients With Chronic Kidney Disease on Dialysis","status":"COMPLETED","sponsor":"Amgen","startDate":"2015-06-10","conditions":"Secondary Hyperparathyroidism, Chronic Kidney Disease","enrollment":28},{"nctId":"NCT01439867","phase":"PHASE2","title":"Safety & Tolerability of Cinacalcet in Pediatric Patients With Chronic Kidney Disease and Secondary Hyperparathyroidism","status":"TERMINATED","sponsor":"Amgen","startDate":"2012-06-22","conditions":"Chronic Kidney Disease, Hyperparathyroidism, Secondary","enrollment":18},{"nctId":"NCT04372225","phase":"","title":"Predicting Risk Factors of Postoperative Hypocalcemia After Total Thyroidectomy","status":"COMPLETED","sponsor":"Aix Marseille Université","startDate":"2020-04-25","conditions":"Hypoparathyroidism","enrollment":477},{"nctId":"NCT00421408","phase":"PHASE1, PHASE2","title":"The Effect of Protein Supplementation on Bone Health in Healthy Older Men and Women","status":"COMPLETED","sponsor":"Yale University","startDate":"2007-02","conditions":"Bone Resorption, Osteoporosis","enrollment":208},{"nctId":"NCT00671944","phase":"PHASE1","title":"Long-term Nutritional Intervention Study to Determine How Protein Affects Calcium Metabolism","status":"COMPLETED","sponsor":"Yale University","startDate":"2003-05","conditions":"Osteoporosis","enrollment":11},{"nctId":"NCT04304573","phase":"","title":"Is Correcting Total Serum Calcium Levels Important After Thyroidectomy","status":"UNKNOWN","sponsor":"University Hospital Sestre Milosrdnice","startDate":"2020-06-09","conditions":"Hypocalcemia, Thyroid, Parathyroid Dysfunction","enrollment":100},{"nctId":"NCT04160637","phase":"","title":"Is There Benefit From Early Postoperative PTH Monitoring?","status":"UNKNOWN","sponsor":"University Hospital Sestre Milosrdnice","startDate":"2019-09-01","conditions":"Hypocalcemia, Thyroid, Postoperative Complications","enrollment":120},{"nctId":"NCT02274623","phase":"PHASE1","title":"Effect of CTAP101 Capsules on Ca/iPTH in Advanced Breast/Prostate Cancer Patients Treated With Denosumab/Zoledronic Acid","status":"COMPLETED","sponsor":"OPKO Health, Inc.","startDate":"2014-12","conditions":"Breast Cancer, Prostate Cancer, Bone Neoplasms","enrollment":33},{"nctId":"NCT00887354","phase":"PHASE4","title":"A Study That Will Compare the Effect of Two Drugs on Participants With Low Bone Mass and a Recent Hip Fracture","status":"COMPLETED","sponsor":"Eli Lilly and Company","startDate":"2009-04","conditions":"Osteoporosis","enrollment":224},{"nctId":"NCT01709110","phase":"PHASE4","title":"VERtebral Fracture Treatment Comparisons in Osteoporotic Women","status":"COMPLETED","sponsor":"Eli Lilly and Company","startDate":"2012-10","conditions":"Postmenopausal Osteoporosis","enrollment":1366},{"nctId":"NCT00395538","phase":"PHASE3","title":"Effects of PTH Replacement on Bone in Hypoparathyroidism","status":"TERMINATED","sponsor":"National Institute of Dental and Craniofacial Research (NIDCR)","startDate":"2006-10-30","conditions":"Hypoparathyroidism, DiGeorge Syndrome","enrollment":46},{"nctId":"NCT01785849","phase":"PHASE3","title":"Efficacy and Safety of Etelcalcetide (AMG 416) in the Treatment of Secondary Hyperparathyroidism (SHPT) in Patients With Chronic Kidney Disease on Hemodialysis","status":"COMPLETED","sponsor":"Amgen","startDate":"2013-03-12","conditions":"Hyperparathyroidism, Secondary","enrollment":508},{"nctId":"NCT01788046","phase":"PHASE3","title":"Efficacy and Safety of Etelcalcetide (AMG 416) in the Treatment of Secondary Hyperparathyroidism (SHPT) in Patients With Chronic Kidney Disease (CKD) on Hemodialysis","status":"COMPLETED","sponsor":"Amgen","startDate":"2013-03-12","conditions":"Hyperparathyroidism, Secondary","enrollment":515},{"nctId":"NCT01896232","phase":"PHASE3","title":"Head-to-Head Study of Etelcalcetide (AMG 416) and Cinacalcet","status":"COMPLETED","sponsor":"Amgen","startDate":"2013-08-13","conditions":"Secondary Hyperparathyroidism, Chronic Kidney Disease","enrollment":683},{"nctId":"NCT03516773","phase":"PHASE2","title":"Oral PTH(1-34) PK and PD Study in Patients With Hypoparathyroidism","status":"COMPLETED","sponsor":"Entera Bio Ltd.","startDate":"2018-06-17","conditions":"Hypoparathyroidism","enrollment":20},{"nctId":"NCT00982722","phase":"NA","title":"Vitamin D Supplementation After Parathyroid Surgery","status":"COMPLETED","sponsor":"Karolinska University Hospital","startDate":"2008-04","conditions":"Primary Hyperparathyroidism","enrollment":150},{"nctId":"NCT03779750","phase":"","title":"Causes Of End Stage Renal Disease In Patients Undergoing Regular Hemodialysis","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2019-01-01","conditions":"End Stage Renal Disease Patients","enrollment":200},{"nctId":"NCT03717116","phase":"","title":"Early Prediction of Hypocalcemia After Thyroidectomy Using Postoperative Second Hour Parathormone","status":"UNKNOWN","sponsor":"Istanbul University","startDate":"2017-09-01","conditions":"Hypocalcemia, Postoperative Parathormone","enrollment":110},{"nctId":"NCT01932970","phase":"PHASE3","title":"Study to Assess the Impact on Calcium Levels When Hemodialysis Patients With Secondary Hyperparathyroidism (SHPT) Switch From Cinacalcet to Etelcalcetide","status":"COMPLETED","sponsor":"Amgen","startDate":"2013-08-12","conditions":"Hyperparathyroidism, Secondary","enrollment":158}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":519,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["PREOS"],"phase":"phase_3","status":"active","brandName":"PTH/Calcium","genericName":"PTH/Calcium","companyName":"Shire","companyId":"shire","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination therapy works by supplementing parathyroid hormone (PTH) to regulate calcium homeostasis and bone metabolism. Used for Hypoparathyroidism, Post-surgical hypoparathyroidism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}