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ProRoot MTA
ProRoot MTA is a mineral trioxide aggregate (MTA) cement that sets through a hydration reaction to form a biocompatible seal in endodontic applications.
ProRoot MTA is a mineral trioxide aggregate (MTA) cement that sets through a hydration reaction to form a biocompatible seal in endodontic applications. Used for Root canal obturation and sealing, Apical plug formation, Perforation repair.
At a glance
| Generic name | ProRoot MTA |
|---|---|
| Also known as | ProRoot® MTA |
| Sponsor | University of the Pacific |
| Drug class | Endodontic cement / Mineral trioxide aggregate |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Endodontics |
| Phase | FDA-approved |
Mechanism of action
ProRoot MTA consists of Portland cement and bismuth oxide particles that hydrate when mixed with water, creating a hard, biocompatible material. It forms a tight seal and promotes periapical healing by stimulating hard tissue formation and providing an antimicrobial barrier. The material is radiopaque due to bismuth oxide and is used primarily for root canal treatment and repair of perforations.
Approved indications
- Root canal obturation and sealing
- Apical plug formation
- Perforation repair
- Pulp capping
- Apicoectomy retrograde filling
Common side effects
- Discoloration of tooth structure
- Difficulty in removal if needed
- Potential cytotoxicity if not fully set
Key clinical trials
- Comparison Of Clinical And Radiological Success Of Pulpotomy Treatments Performed With Proroot MTA, NeoPUTTY MTA, TheraCal PT In Primary Teeth (NA)
- A Comparative Analysis of Biomaterials for Retrograde Filling in Apical Surgery. (NA)
- Pulpotomy Materials in Primary Molars (NA)
- The Effect of Different Treatment Methods on the Apical Closure and Treatment Success in Permanent First Molars (NA)
- Evaluation of Primary Tooth Pulpotomy With Resin Modified Calcium Silicate (NA)
- Postoperative Pain After Full Pulpotomy With TheraCal PT, Biodentin, and MTA (NA)
- COMPARISON of MINERAL TRIOXIDE AGGREGATE and CALCIUM HYDROXIDE AS INDIRECT PULP CAPPING AGENTS in PRIMARY MOLARS (PHASE4)
- COMPARATIVE EVALUATION OF DIRECT PULP CAPPING AND COMPLETE PULPOTOMY IN MATURE PERMANENT MANDIBULAR MOLARS WITH CLINICAL SIGNS INDICATIVE OF MODERATE PULPITIS (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ProRoot MTA CI brief — competitive landscape report
- ProRoot MTA updates RSS · CI watch RSS
- University of the Pacific portfolio CI