{"id":"proroot-mta","safety":{"commonSideEffects":[{"rate":null,"effect":"Discoloration of tooth structure"},{"rate":null,"effect":"Difficulty in removal if needed"},{"rate":null,"effect":"Potential cytotoxicity if not fully set"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ProRoot MTA consists of Portland cement and bismuth oxide particles that hydrate when mixed with water, creating a hard, biocompatible material. It forms a tight seal and promotes periapical healing by stimulating hard tissue formation and providing an antimicrobial barrier. The material is radiopaque due to bismuth oxide and is used primarily for root canal treatment and repair of perforations.","oneSentence":"ProRoot MTA is a mineral trioxide aggregate (MTA) cement that sets through a hydration reaction to form a biocompatible seal in endodontic applications.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:03:11.835Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Root canal obturation and sealing"},{"name":"Apical plug formation"},{"name":"Perforation repair"},{"name":"Pulp capping"},{"name":"Apicoectomy retrograde filling"}]},"trialDetails":[{"nctId":"NCT07260357","phase":"NA","title":"Comparison Of Clinical And Radiological Success Of Pulpotomy Treatments Performed With Proroot MTA, NeoPUTTY MTA, TheraCal PT In Primary Teeth","status":"COMPLETED","sponsor":"Necmettin Erbakan University","startDate":"2024-01-01","conditions":"Dentin Caries","enrollment":90},{"nctId":"NCT07246512","phase":"NA","title":"A Comparative Analysis of Biomaterials for Retrograde Filling in Apical Surgery.","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Valencia","startDate":"2024-02-08","conditions":"Periapical Lesion","enrollment":110},{"nctId":"NCT07120321","phase":"NA","title":"Pulpotomy Materials in Primary Molars","status":"COMPLETED","sponsor":"Sacide Duman","startDate":"2022-01-01","conditions":"Dental Caries, Pulpitis","enrollment":22},{"nctId":"NCT06575062","phase":"NA","title":"The Effect of Different Treatment Methods on the Apical Closure and Treatment Success in Permanent First Molars","status":"COMPLETED","sponsor":"Ataturk University","startDate":"2023-06-05","conditions":"Symptomatic Reversible Pulpitis (Disorder)","enrollment":60},{"nctId":"NCT06874062","phase":"NA","title":"Evaluation of Primary Tooth Pulpotomy With Resin Modified Calcium Silicate","status":"COMPLETED","sponsor":"Ataturk University","startDate":"2023-06-20","conditions":"Pulpotomy","enrollment":70},{"nctId":"NCT06880471","phase":"NA","title":"Postoperative Pain After Full Pulpotomy With TheraCal PT, Biodentin, and MTA","status":"RECRUITING","sponsor":"Cumhuriyet University","startDate":"2024-12-12","conditions":"Symptomatic Irreversible Pulpitis (SIP)","enrollment":51},{"nctId":"NCT06807320","phase":"PHASE4","title":"COMPARISON of MINERAL TRIOXIDE AGGREGATE and CALCIUM HYDROXIDE AS INDIRECT PULP CAPPING AGENTS in PRIMARY MOLARS","status":"COMPLETED","sponsor":"Shaheed Zulfiqar Ali Bhutto Medical University","startDate":"2022-01-01","conditions":"Indirect Pulp Cap","enrollment":40},{"nctId":"NCT06447753","phase":"NA","title":"COMPARATIVE EVALUATION OF DIRECT PULP CAPPING AND COMPLETE PULPOTOMY IN MATURE PERMANENT MANDIBULAR MOLARS WITH CLINICAL SIGNS INDICATIVE OF MODERATE PULPITIS","status":"RECRUITING","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2023-06-01","conditions":"Moderate Pulpitis","enrollment":92},{"nctId":"NCT05149651","phase":"PHASE4","title":"Efficacy of Totalfill® and ProRoot MTA® as Pulpotomy Agent in Primary Molars","status":"COMPLETED","sponsor":"University Ghent","startDate":"2017-01-01","conditions":"Extensively Decayed Primary Molars","enrollment":36},{"nctId":"NCT05145686","phase":"PHASE1, PHASE2","title":"The Role of Matrix Metalloproteinases on the Primary Teeth Pulpotomy Treatments","status":"COMPLETED","sponsor":"Ege University","startDate":"2018-01-01","conditions":"Reversible Pulpitis","enrollment":57},{"nctId":"NCT04903808","phase":"PHASE2, PHASE3","title":"Clinical And Cost- Effectiveness of Allium Sativum Oil (Garlic Oil ) Versus Mineral Trioxide Aggregate in Primary Molars Pulpotomy in Group of Egyptian Children : A Randomised Clinical Pilot Study.","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-09","conditions":"Carious Primary Molars","enrollment":26},{"nctId":"NCT04652323","phase":"","title":"Tissue Reactions to Calcium Silicate","status":"COMPLETED","sponsor":"Eskisehir Osmangazi University","startDate":"2019-04-01","conditions":"Dental Materials, Mineral Trioxide Aggregate","enrollment":24},{"nctId":"NCT04270318","phase":"NA","title":"Sodium Hypoclorite as an Antibacterial Agent Prior to Pulpotomies","status":"COMPLETED","sponsor":"Izmir Katip Celebi University","startDate":"2012-09","conditions":"Pulpotomy, Primary Teeth","enrollment":64},{"nctId":"NCT04243993","phase":"NA","title":"Clinical Outcomes of Bio-MA and ProRoot MTA in Endodontic Treatment","status":"UNKNOWN","sponsor":"Mahidol University","startDate":"2017-07-01","conditions":"Clinical Outcome, Endodontic Disease","enrollment":60},{"nctId":"NCT04198298","phase":"PHASE4","title":"Prospective Clinical Trial of Three Apical Sealing Materials","status":"COMPLETED","sponsor":"University of the Pacific","startDate":"2014-11-02","conditions":"Periapical Abscess","enrollment":59},{"nctId":"NCT01224925","phase":"NA","title":"RCT of Pulp Capping Over Carious Exposure in Adults","status":"COMPLETED","sponsor":"University of Tromso","startDate":"2010-10-18","conditions":"Carious Exposure, Human Permanent First and Second Molars, Mature Teeth","enrollment":80},{"nctId":"NCT03849222","phase":"PHASE2, PHASE3","title":"Evaluation the Effect of Using of Apical Matrix With Apexification Procedure on Apical Healing of Necrotic Immature Teeth","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2013-08-20","conditions":"Pulp Necrosis, Apexification","enrollment":32},{"nctId":"NCT03606681","phase":"NA","title":"Clinical and Radiographic Evaluation of Indirect Pulp Capping in Primary and Permanent Teeth With Different Materials","status":"COMPLETED","sponsor":"Altinbas University","startDate":"2013-07","conditions":"Dental Pulp Capping","enrollment":300},{"nctId":"NCT03395496","phase":"EARLY_PHASE1","title":"Comparison of Biodentine and MTA Pulpotomies in the Primary Molar Teeth 3 Year Follow up","status":"COMPLETED","sponsor":"Istanbul University","startDate":"2013-05-01","conditions":"Pulpotomy, Dental Caries","enrollment":200},{"nctId":"NCT02625298","phase":"PHASE2","title":"Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth","status":"COMPLETED","sponsor":"Association of Paediatric and Preventive Dentists of Serbia","startDate":"2010-09","conditions":"Periapical Diseases","enrollment":24},{"nctId":"NCT03254290","phase":"EARLY_PHASE1","title":"Color Stability of NeoMTA Pulpotomized Primary Teeth","status":"UNKNOWN","sponsor":"Texas A & M University Baylor College Of Dentistry","startDate":"2017-10-01","conditions":"Dental Caries Extending to Pulp","enrollment":15},{"nctId":"NCT03135626","phase":"PHASE3","title":"Comparison of The Success Rates of Four Different Pulpotomy Techniques","status":"COMPLETED","sponsor":"Istanbul University","startDate":"2013-03-15","conditions":"Extensive Decay in Primary Molars","enrollment":38},{"nctId":"NCT02702505","phase":"PHASE4","title":"Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT","status":"UNKNOWN","sponsor":"Texas A & M University Baylor College Of Dentistry","startDate":"2014-11","conditions":"Reversible Pulpitis, Dental Pulp Diseases","enrollment":50},{"nctId":"NCT02291120","phase":"PHASE4","title":"MEDCEM PC and MTA in Pulpotomies of Primary Molars","status":"UNKNOWN","sponsor":"Universitat Internacional de Catalunya","startDate":"2014-03","conditions":"Evaluate the Effects of MEDCEM PC and MTA in Pulpotomies of Primary Molars.","enrollment":80},{"nctId":"NCT01730287","phase":"PHASE2","title":"Effect Of Different Lining Materials in Stepwise Excavation","status":"UNKNOWN","sponsor":"Azad University of Medical Sciences","startDate":"2010-05","conditions":"Dental Pulp Necrosis","enrollment":100},{"nctId":"NCT00972556","phase":"NA","title":"Comparison of Mineral Trioxide Aggregate (MTA) and 20% Formocresol (FC) in Pulpotomized Human Primary Molars","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2009-09","conditions":"Dental Caries, Pulpitis","enrollment":200},{"nctId":"NCT01420718","phase":"PHASE2, PHASE3","title":"Partial Pulpotomy on Caries Free Human Teeth","status":"COMPLETED","sponsor":"Islamic Azad University, Sanandaj","startDate":"2011-06","conditions":"Dentin Bridge, Pulpitis","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ProRoot® MTA"],"phase":"marketed","status":"active","brandName":"ProRoot MTA","genericName":"ProRoot MTA","companyName":"University of the Pacific","companyId":"university-of-the-pacific","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ProRoot MTA is a mineral trioxide aggregate (MTA) cement that sets through a hydration reaction to form a biocompatible seal in endodontic applications. Used for Root canal obturation and sealing, Apical plug formation, Perforation repair.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}