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propofol，remifentanil，cis atracurium
This is a combination of three anesthetic/neuromuscular agents: propofol (GABA agonist for sedation), remifentanil (opioid for analgesia), and cisatracurium (neuromuscular blocker for paralysis).
This is a combination of three anesthetic/neuromuscular agents: propofol (GABA agonist for sedation), remifentanil (opioid for analgesia), and cisatracurium (neuromuscular blocker for paralysis). Used for Induction and maintenance of general anesthesia for surgical procedures, Sedation in mechanically ventilated patients in intensive care settings.
At a glance
| Generic name | propofol，remifentanil，cis atracurium |
|---|---|
| Also known as | Propofol Injection，Ruifen，Cisatracurium Besylate Injection |
| Sponsor | Tang-Du Hospital |
| Drug class | General anesthetic combination (GABA agonist + opioid + neuromuscular blocker) |
| Target | GABA-A receptor (propofol); mu-opioid receptor (remifentanil); nicotinic acetylcholine receptor at neuromuscular junction (cisatracurium) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol enhances inhibitory GABA signaling in the central nervous system to produce sedation and hypnosis. Remifentanil is a potent synthetic opioid that binds mu-opioid receptors to provide rapid analgesia and anxiolysis. Cisatracurium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the neuromuscular junction, producing skeletal muscle paralysis. Together, these agents are used for induction and maintenance of general anesthesia.
Approved indications
- Induction and maintenance of general anesthesia for surgical procedures
- Sedation in mechanically ventilated patients in intensive care settings
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain (propofol)
- Postoperative nausea and vomiting
- Muscle rigidity (remifentanil)
- Histamine release (cisatracurium)
Key clinical trials
- Different Anesthetic Technique For ERCP (NA)
- Ultrasound-assisted Bilateral Transversus Abdominis Plane Block for Open Prostatectomy (NA)
- Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus (PHASE4)
- Effect of Epidural Anesthesia and Analgesia on Patients' Outcomes After Liver Resection (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
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- propofol，remifentanil，cis atracurium CI brief — competitive landscape report
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