{"id":"propofol-remifentanil-cis-atracurium","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Hypotension"},{"rate":"common","effect":"Respiratory depression"},{"rate":"5-15","effect":"Bradycardia"},{"rate":"10-20","effect":"Injection site pain (propofol)"},{"rate":"10-30","effect":"Postoperative nausea and vomiting"},{"rate":"5-10","effect":"Muscle rigidity (remifentanil)"},{"rate":"rare","effect":"Histamine release (cisatracurium)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Propofol enhances inhibitory GABA signaling in the central nervous system to produce sedation and hypnosis. Remifentanil is a potent synthetic opioid that binds mu-opioid receptors to provide rapid analgesia and anxiolysis. Cisatracurium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the neuromuscular junction, producing skeletal muscle paralysis. Together, these agents are used for induction and maintenance of general anesthesia.","oneSentence":"This is a combination of three anesthetic/neuromuscular agents: propofol (GABA agonist for sedation), remifentanil (opioid for analgesia), and cisatracurium (neuromuscular blocker for paralysis).","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:36:43.691Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia for surgical procedures"},{"name":"Sedation in mechanically ventilated patients in intensive care settings"}]},"trialDetails":[{"nctId":"NCT04087668","phase":"NA","title":"Different Anesthetic Technique For ERCP","status":"COMPLETED","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2019-09-01","conditions":"Anesthesia; Adverse Effect","enrollment":405},{"nctId":"NCT01625572","phase":"NA","title":"Ultrasound-assisted Bilateral Transversus Abdominis Plane Block for Open Prostatectomy","status":"COMPLETED","sponsor":"Charite University, Berlin, Germany","startDate":"2012-07","conditions":"Prostatectomy, Transversus Abdominis Plane Blockade, Pain","enrollment":66},{"nctId":"NCT02518789","phase":"PHASE4","title":"Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus","status":"UNKNOWN","sponsor":"Tang-Du Hospital","startDate":"2015-09","conditions":"Myoclonus","enrollment":132},{"nctId":"NCT01617811","phase":"NA","title":"Effect of Epidural Anesthesia and Analgesia on Patients' Outcomes After Liver Resection","status":"COMPLETED","sponsor":"Sir Run Run Shaw Hospital","startDate":"2007-08","conditions":"Hepatectomy","enrollment":26}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Propofol Injection，Ruifen，Cisatracurium Besylate Injection"],"phase":"marketed","status":"active","brandName":"propofol，remifentanil，cis atracurium","genericName":"propofol，remifentanil，cis atracurium","companyName":"Tang-Du Hospital","companyId":"tang-du-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of three anesthetic/neuromuscular agents: propofol (GABA agonist for sedation), remifentanil (opioid for analgesia), and cisatracurium (neuromuscular blocker for paralysis). Used for Induction and maintenance of general anesthesia for surgical procedures, Sedation in mechanically ventilated patients in intensive care settings.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}