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Propofol-based total intravenous anesthesia
Propofol acts as a non-selective GABA_A receptor agonist, enhancing the inhibitory effects of GABA to induce sedation and anesthesia.
Propofol acts as a non-selective GABA_A receptor agonist, enhancing the inhibitory effects of GABA to induce sedation and anesthesia. Used for General anesthesia for surgical procedures, Procedural sedation.
At a glance
| Generic name | Propofol-based total intravenous anesthesia |
|---|---|
| Also known as | Propofol |
| Sponsor | The Cleveland Clinic |
| Drug class | GABA_A receptor agonist |
| Target | GABA_A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Propofol binds to the GABA_A receptor, increasing the frequency of chloride channel opening and leading to hyperpolarization of neurons, which results in sedation and anesthesia. This mechanism is thought to be responsible for its anesthetic effects, although the exact mechanisms are not fully understood.
Approved indications
- General anesthesia for surgical procedures
- Procedural sedation
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Headache
Key clinical trials
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (NA)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Effect of Total Intravenous Anesthesia vs Inhalational Anesthesia on the Level of Inflammatory Markers (NA)
- Ciprofol Based on Total Intravenous Anesthesia During Pediatric Laparoscopic Surgery (NA)
- Differences in Speed of Recovery From Anesthesia for Intraoral Surgery (NA)
- Comparison of Emergence Agitation Between Remimazolam With Flumazenil and Propofol-based Total Intravenous Anesthesia in Patients Undergoing Nasal Surgery (NA)
- Total Intravenous Anesthesia in Patients Undergoing Craniotomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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