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prophylactic heparin
prophylactic heparin is a Anticoagulant Small molecule drug developed by Matthew Neal MD. It is currently FDA-approved for Prophylaxis of venous thromboembolism in surgical patients, Prophylaxis of thromboembolism in medical patients at risk, Prevention of clotting in extracorporeal circulation. Also known as: enoxaparin, dalteparin, Tinzaparin, Fondparinux.
Prophylactic heparin inhibits blood clotting by enhancing the activity of antithrombin III, preventing thrombus formation.
Prophylactic heparin is used to study conditions such as anemia, sickle cell, acute chest syndrome, and acute exacerbation of COPD. It works by activating antithrombin-III, a protein that helps regulate blood clotting, through its oligosaccharide modality.
At a glance
| Generic name | prophylactic heparin |
|---|---|
| Also known as | enoxaparin, dalteparin, Tinzaparin, Fondparinux, Heparin |
| Sponsor | Matthew Neal MD |
| Drug class | Anticoagulant |
| Target | Antithrombin III (indirect); Factors IIa and Xa |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Heparin is an anticoagulant that potentiates antithrombin III, a natural inhibitor of several blood coagulation factors (particularly factors IIa and Xa). By accelerating the inactivation of these clotting factors, heparin reduces the formation of fibrin clots and prevents thromboembolism. When used prophylactically, it is administered at lower doses to prevent clot formation in high-risk patients without causing therapeutic anticoagulation.
Approved indications
- Prophylaxis of venous thromboembolism in surgical patients
- Prophylaxis of thromboembolism in medical patients at risk
- Prevention of clotting in extracorporeal circulation
Common side effects
- Bleeding
- Heparin-induced thrombocytopenia (HIT)
- Thrombosis
- Injection site reactions
- Osteoporosis (with prolonged use)
Key clinical trials
- Timing of Venous Thromboembolism Prophylaxis in Patients With Hypertensive Intracerebral Hemorrhage (NA)
- Intravenous Immunoglobulin for the Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis (PHASE3)
- A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer (PHASE2)
- Efficacy and Safety of Extended Anticoagulant Therapy in Cancer Associated Thrombosis in Thai Population
- Comparison of Apixaban Versus Enoxaparin (NA)
- Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial (PHASE2)
- Prophylactic ANTicoagulation With HEparine in Critically Ill Patients With Renal Impairment
- Anticoagulation-free VV ECMO for Acute Respiratory Failure (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- prophylactic heparin CI brief — competitive landscape report
- prophylactic heparin updates RSS · CI watch RSS
- Matthew Neal MD portfolio CI
Frequently asked questions about prophylactic heparin
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Related
- Drug class: All Anticoagulant drugs
- Target: All drugs targeting Antithrombin III (indirect); Factors IIa and Xa
- Manufacturer: Matthew Neal MD — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Prophylaxis of venous thromboembolism in surgical patients
- Indication: Drugs for Prophylaxis of thromboembolism in medical patients at risk
- Indication: Drugs for Prevention of clotting in extracorporeal circulation
- Also known as: enoxaparin, dalteparin, Tinzaparin, Fondparinux, Heparin
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing