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prolotherapy solution of 20% dextrose
A 20% dextrose solution injected into damaged connective tissues stimulates a local inflammatory response that promotes tissue repair and regeneration.
A 20% dextrose solution injected into damaged connective tissues stimulates a local inflammatory response that promotes tissue repair and regeneration. Used for Chronic musculoskeletal pain from ligamentous laxity, Tendon injuries, Joint instability.
At a glance
| Generic name | prolotherapy solution of 20% dextrose |
|---|---|
| Also known as | Dextrose 20% solution |
| Sponsor | Hadassah Medical Organization |
| Drug class | Regenerative medicine agent |
| Modality | Small molecule |
| Therapeutic area | Orthopedics / Musculoskeletal |
| Phase | FDA-approved |
Mechanism of action
Prolotherapy (proliferative therapy) works by inducing controlled inflammation at the injection site, which triggers the body's natural healing cascade. The hypertonic dextrose solution causes osmotic stress and irritation to ligaments, tendons, and other connective tissues, activating fibroblasts and promoting collagen deposition and tissue strengthening. This mechanism is intended to stabilize joints and reduce pain from chronic ligamentous laxity or tendon injuries.
Approved indications
- Chronic musculoskeletal pain from ligamentous laxity
- Tendon injuries
- Joint instability
Common side effects
- Injection site pain or soreness
- Temporary increased pain at treatment site
- Swelling or inflammation at injection site
Key clinical trials
- Combined Effect of Prolotherapy and Personalized Physical Activity on Knee Osteoarthritis Progression (NA)
- Effects of Intra-articular Hypertonic Dextrose and Hyaluronic Acid on Primary Knee Osteoarthritis. (PHASE3)
- Is the Combine Prolotherapy More Effective Than the Traditional Prolotherapy in Patients With Temporomandibular Joint Hypermobility? (PHASE4)
- Comparison of the Efficacy of Dextrose Prolotherapy and Mesotherapy in Lateral Epicondylitis (NA)
- Therapeutic Effect of Using Injectable Hypertonic Saline 5% Versus Injectable Dextrose 20% on Pain in Painful Cases of Disc Displacement with Reduction (NA)
- Precision Medicine for Nociception, Sngception and Proprioception. (NA)
- Comparison of the Effectiveness of Local Ozone Injection and Dextrose Prolotherapy Injection in Chronic Plantar Fasciitis (NA)
- Effects of Dextrose Prolotherapy in Patients With Knee Osteoarthritis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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