{"id":"prolotherapy-solution-of-20-dextrose","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or soreness"},{"rate":null,"effect":"Temporary increased pain at treatment site"},{"rate":null,"effect":"Swelling or inflammation at injection site"}]},"_chembl":{"chemblId":"CHEMBL2108978","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prolotherapy (proliferative therapy) works by inducing controlled inflammation at the injection site, which triggers the body's natural healing cascade. The hypertonic dextrose solution causes osmotic stress and irritation to ligaments, tendons, and other connective tissues, activating fibroblasts and promoting collagen deposition and tissue strengthening. This mechanism is intended to stabilize joints and reduce pain from chronic ligamentous laxity or tendon injuries.","oneSentence":"A 20% dextrose solution injected into damaged connective tissues stimulates a local inflammatory response that promotes tissue repair and regeneration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:52.623Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic musculoskeletal pain from ligamentous laxity"},{"name":"Tendon injuries"},{"name":"Joint instability"}]},"trialDetails":[{"nctId":"NCT07355712","phase":"NA","title":"Combined Effect of Prolotherapy and Personalized Physical Activity on Knee Osteoarthritis Progression","status":"COMPLETED","sponsor":"Gadjah Mada University","startDate":"2024-07-10","conditions":"Prolotherapy","enrollment":74},{"nctId":"NCT07102225","phase":"PHASE3","title":"Effects of Intra-articular Hypertonic Dextrose and Hyaluronic Acid on Primary Knee 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Dextrose 20% on Pain in Painful Cases of Disc Displacement with Reduction","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-08-20","conditions":"TMJ Disc Displacement with Reduction","enrollment":20},{"nctId":"NCT06161038","phase":"NA","title":"Precision Medicine for Nociception, Sngception and Proprioception.","status":"RECRUITING","sponsor":"National Taiwan University Hospital","startDate":"2023-10-01","conditions":"Rehabilitation, Pain, Shoulder, Pain, Chronic","enrollment":160},{"nctId":"NCT05984121","phase":"NA","title":"Comparison of the Effectiveness of Local Ozone Injection and Dextrose Prolotherapy Injection in Chronic Plantar Fasciitis","status":"COMPLETED","sponsor":"Ahi Evran University Education and Research Hospital","startDate":"2023-08-05","conditions":"Plantar Fascitis","enrollment":60},{"nctId":"NCT06063356","phase":"NA","title":"Effects of Dextrose Prolotherapy in Patients With Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Istanbul University","startDate":"2023-08-15","conditions":"Knee Osteoarthritis","enrollment":66},{"nctId":"NCT05966948","phase":"NA","title":"HDP vs NS Intra-articular Injection Among KOA With Obese Patient","status":"COMPLETED","sponsor":"Rumah Sakit Umum Daerah Haji Provinsi Jawa Timur, Indonesia","startDate":"2023-05-01","conditions":"Knee Osteoarthritis, Obesity","enrollment":40},{"nctId":"NCT03839108","phase":"NA","title":"Comparison of Effect of Prolotherapy and Paraffin Waxes for Hand Osteoarthritis","status":"COMPLETED","sponsor":"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","startDate":"2018-12-14","conditions":"Hand Osteoarthritis","enrollment":42},{"nctId":"NCT01934868","phase":"PHASE4","title":"Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg","status":"COMPLETED","sponsor":"Hadassah Medical Organization","startDate":"2013-12-01","conditions":"Sciatica, Spinal Stenosis of Lumbar Region, Degeneration of Lumbar or Lumbosacral Intervertebral Disc","enrollment":110},{"nctId":"NCT05131269","phase":"PHASE4","title":"Prolotherapy Intervention in Patient With Frozen Shoulder","status":"COMPLETED","sponsor":"Bumi Herman","startDate":"2021-12-01","conditions":"Frozen Shoulder","enrollment":32},{"nctId":"NCT04062838","phase":"PHASE4","title":"Prolotherapy for the Treatment of Partial Rotator Cuff Tears","status":"WITHDRAWN","sponsor":"Hadassah Medical Organization","startDate":"2020-08-01","conditions":"Rotator Cuff Tear","enrollment":""},{"nctId":"NCT03931811","phase":"NA","title":"Effects of Short Wave Diathermy Added on Dextrose Prolotherapy Injections in Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"Ege University","startDate":"2017-04-04","conditions":"Knee Osteoarthritis","enrollment":63},{"nctId":"NCT01617356","phase":"NA","title":"Treatment of Temporomandibular Dysfunction With Hypertonic Dextrose Injection","status":"COMPLETED","sponsor":"Frusso, Ricardo, M.D.","startDate":"2012-06","conditions":"Temporomandibular Joint Disorders","enrollment":30},{"nctId":"NCT01706172","phase":"PHASE2, PHASE3","title":"Treatment of Temporomandibular Dysfunction With Hypertonic Dextrose Injection","status":"COMPLETED","sponsor":"Chisel Peak Medical Clinic","startDate":"2013-01","conditions":"Temporomandibular Joint Disorders","enrollment":42},{"nctId":"NCT02052089","phase":"NA","title":"Comparative Study for the Optimal Treatment Method of Lateral Epicondylosis","status":"COMPLETED","sponsor":"CM Chungmu Hospital","startDate":"2009-03","conditions":"Tennis Elbow","enrollment":231}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dextrose 20% solution"],"phase":"marketed","status":"active","brandName":"prolotherapy solution of 20% dextrose","genericName":"prolotherapy solution of 20% dextrose","companyName":"Hadassah Medical Organization","companyId":"hadassah-medical-organization","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A 20% dextrose solution injected into damaged connective tissues stimulates a local inflammatory response that promotes tissue repair and regeneration. Used for Chronic musculoskeletal pain from ligamentous laxity, Tendon injuries, Joint instability.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}