Last reviewed · How we verify
Progesterone Vaginal Gel with Applicator
Progesterone acts as a steroid hormone that helps to maintain the pregnancy by preparing the uterus to implant a fertilized egg and supporting embryonic development.
Progesterone acts as a steroid hormone that helps to maintain the pregnancy by preparing the uterus to implant a fertilized egg and supporting embryonic development. Used for Treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance.
At a glance
| Generic name | Progesterone Vaginal Gel with Applicator |
|---|---|
| Also known as | Crinone |
| Sponsor | IBSA Institut Biochimique SA |
| Drug class | Progestogen |
| Modality | Small molecule |
| Therapeutic area | Women's Health |
| Phase | Phase 3 |
Mechanism of action
Progesterone is a naturally occurring hormone in the body that plays a crucial role in the menstrual cycle and pregnancy. It helps to thicken the uterine lining, preparing it for implantation of a fertilized egg, and supports embryonic development during early pregnancy.
Approved indications
- Treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance
Common side effects
- Vaginal discharge
- Vaginal irritation
Key clinical trials
- Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer. (PHASE3)
- Randomized Trial of Maternal Progesterone Therapy (PHASE2)
- Uterine Electrical Activity Before and After Progesterone Treatment for Preterm Labor (NA)
- Sexual Absorption of Vaginal Progesterone (PHASE4)
- An Efficacy and Safety Study of Corifollitropin Alfa (MK-8962) in Contrast to Recombinant FSH for Use in Controlled Ovarian Stimulation of Indian Women (P07056, Also Known as MK-8962-029) (PHASE3)
- Vaginal Progesterone Supplementation in Women With PCOS Undergoing Ovulation Induction With Letrozole (PHASE2, PHASE3)
- Prevention of Ovulation Achieved by Single Intra-vaginal Administration of Levogel as Compared to Oral LNG (PHASE1)
- Contraception and Menstrual Cycle Effect on Pharmacokinetics, Pharmacodynamics and Safety in Tenofovir Vaginal Gel Use (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: