{"id":"progesterone-vaginal-gel-with-applicator","safety":{"commonSideEffects":[{"rate":"null","effect":"Vaginal discharge"},{"rate":"null","effect":"Vaginal irritation"}]},"_chembl":{"chemblId":"CHEMBL103","moleculeType":"Small molecule","molecularWeight":"314.47"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Progesterone is a naturally occurring hormone in the body that plays a crucial role in the menstrual cycle and pregnancy. It helps to thicken the uterine lining, preparing it for implantation of a fertilized egg, and supports embryonic development during early pregnancy.","oneSentence":"Progesterone acts as a steroid hormone that helps to maintain the pregnancy by preparing the uterus to implant a fertilized egg and supporting embryonic development.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:30:21.922Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance"}]},"trialDetails":[{"nctId":"NCT04549116","phase":"PHASE3","title":"Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer.","status":"ACTIVE_NOT_RECRUITING","sponsor":"IBSA Institut Biochimique SA","startDate":"2022-10-12","conditions":"Infertility","enrollment":680},{"nctId":"NCT02133573","phase":"PHASE2","title":"Randomized Trial of Maternal Progesterone Therapy","status":"COMPLETED","sponsor":"Children's Hospital of Philadelphia","startDate":"2014-07","conditions":"Congenital Heart Disease, Periventricular Leucomalacia, Brain Development","enrollment":102},{"nctId":"NCT01406197","phase":"NA","title":"Uterine Electrical Activity Before and After Progesterone Treatment for Preterm Labor","status":"WITHDRAWN","sponsor":"St. Joseph's Hospital and Medical Center, Phoenix","startDate":"2011-07","conditions":"Preterm Labor","enrollment":""},{"nctId":"NCT01959464","phase":"PHASE4","title":"Sexual Absorption of Vaginal Progesterone","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2008-11","conditions":"Infertility, Pregnancy","enrollment":20},{"nctId":"NCT01599494","phase":"PHASE3","title":"An Efficacy and Safety Study of Corifollitropin Alfa (MK-8962) in Contrast to Recombinant FSH for Use in Controlled Ovarian Stimulation of Indian Women (P07056, Also Known as MK-8962-029)","status":"WITHDRAWN","sponsor":"Organon and Co","startDate":"2014-03","conditions":"Infertility","enrollment":""},{"nctId":"NCT03440359","phase":"PHASE2, PHASE3","title":"Vaginal Progesterone Supplementation in Women With PCOS Undergoing Ovulation Induction With Letrozole","status":"COMPLETED","sponsor":"Eastern Virginia Medical School","startDate":"2012-07-06","conditions":"Polycystic Ovary Syndrome","enrollment":52},{"nctId":"NCT01286948","phase":"PHASE1","title":"Prevention of Ovulation Achieved by Single Intra-vaginal Administration of Levogel as Compared to Oral LNG","status":"COMPLETED","sponsor":"Population Council","startDate":"2011-01","conditions":"Female Contraception","enrollment":20},{"nctId":"NCT01421368","phase":"PHASE1","title":"Contraception and Menstrual Cycle Effect on Pharmacokinetics, Pharmacodynamics and Safety in Tenofovir Vaginal Gel Use","status":"COMPLETED","sponsor":"CONRAD","startDate":"2012-03","conditions":"HIV Prevention","enrollment":72},{"nctId":"NCT01367912","phase":"NA","title":"Timing of Estrogen Support During the Luteal Phase of in Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) Cycle","status":"COMPLETED","sponsor":"Zekai Tahir Burak Women's Health Research and Education Hospital","startDate":"2008-02","conditions":"Infertility","enrollment":301}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Crinone"],"phase":"phase_3","status":"active","brandName":"Progesterone Vaginal Gel with Applicator","genericName":"Progesterone Vaginal Gel with Applicator","companyName":"IBSA Institut Biochimique SA","companyId":"ibsa-institut-biochimique-sa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Progesterone acts as a steroid hormone that helps to maintain the pregnancy by preparing the uterus to implant a fertilized egg and supporting embryonic development. Used for Treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}