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Progesterone Vaginal Gel [Crinone]

Memorial Sisli Hospital, Istanbul · FDA-approved active Small molecule

Progesterone Vaginal Gel [Crinone] is a Progestin; Progesterone receptor agonist Small molecule drug developed by Memorial Sisli Hospital, Istanbul. It is currently FDA-approved for Luteal phase support in assisted reproductive technology (ART) cycles, Infertility due to inadequate luteal phase. Also known as: Crinone %8 vaginal progesterone gel.

Progesterone binds to progesterone receptors in the uterus to support the luteal phase and maintain pregnancy.

Progesterone binds to progesterone receptors in the uterus to support the luteal phase and maintain pregnancy. Used for Luteal phase support in assisted reproductive technology (ART) cycles, Infertility due to inadequate luteal phase.

At a glance

Generic nameProgesterone Vaginal Gel [Crinone]
Also known asCrinone %8 vaginal progesterone gel
SponsorMemorial Sisli Hospital, Istanbul
Drug classProgestin; Progesterone receptor agonist
TargetProgesterone receptor (PR)
ModalitySmall molecule
Therapeutic areaReproductive/Fertility
PhaseFDA-approved

Mechanism of action

Progesterone is a naturally occurring steroid hormone that acts as a ligand for intracellular progesterone receptors, primarily in the endometrium. This binding promotes endometrial secretion, suppresses uterine contractions, and maintains the uterine environment necessary for embryo implantation and early pregnancy maintenance. The vaginal gel formulation (Crinone) delivers progesterone directly to the reproductive tract for local and systemic absorption.

Approved indications

Common side effects

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Frequently asked questions about Progesterone Vaginal Gel [Crinone]

What is Progesterone Vaginal Gel [Crinone]?

Progesterone Vaginal Gel [Crinone] is a Progestin; Progesterone receptor agonist drug developed by Memorial Sisli Hospital, Istanbul, indicated for Luteal phase support in assisted reproductive technology (ART) cycles, Infertility due to inadequate luteal phase.

How does Progesterone Vaginal Gel [Crinone] work?

Progesterone binds to progesterone receptors in the uterus to support the luteal phase and maintain pregnancy.

What is Progesterone Vaginal Gel [Crinone] used for?

Progesterone Vaginal Gel [Crinone] is indicated for Luteal phase support in assisted reproductive technology (ART) cycles, Infertility due to inadequate luteal phase.

Who makes Progesterone Vaginal Gel [Crinone]?

Progesterone Vaginal Gel [Crinone] is developed and marketed by Memorial Sisli Hospital, Istanbul (see full Memorial Sisli Hospital, Istanbul pipeline at /company/memorial-sisli-hospital-istanbul).

Is Progesterone Vaginal Gel [Crinone] also known as anything else?

Progesterone Vaginal Gel [Crinone] is also known as Crinone %8 vaginal progesterone gel.

What drug class is Progesterone Vaginal Gel [Crinone] in?

Progesterone Vaginal Gel [Crinone] belongs to the Progestin; Progesterone receptor agonist class. See all Progestin; Progesterone receptor agonist drugs at /class/progestin-progesterone-receptor-agonist.

What development phase is Progesterone Vaginal Gel [Crinone] in?

Progesterone Vaginal Gel [Crinone] is FDA-approved (marketed).

What are the side effects of Progesterone Vaginal Gel [Crinone]?

Common side effects of Progesterone Vaginal Gel [Crinone] include Vaginal irritation or discharge, Headache, Breast tenderness, Abdominal pain or cramping.

What does Progesterone Vaginal Gel [Crinone] target?

Progesterone Vaginal Gel [Crinone] targets Progesterone receptor (PR) and is a Progestin; Progesterone receptor agonist.

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