{"id":"progesterone-vaginal-gel-crinone","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation or discharge"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Abdominal pain or cramping"}]},"_chembl":{"chemblId":"CHEMBL103","moleculeType":"Small molecule","molecularWeight":"314.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Progesterone is a naturally occurring steroid hormone that acts as a ligand for intracellular progesterone receptors, primarily in the endometrium. This binding promotes endometrial secretion, suppresses uterine contractions, and maintains the uterine environment necessary for embryo implantation and early pregnancy maintenance. The vaginal gel formulation (Crinone) delivers progesterone directly to the reproductive tract for local and systemic absorption.","oneSentence":"Progesterone binds to progesterone receptors in the uterus to support the luteal phase and maintain pregnancy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:47.707Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Luteal phase support in assisted reproductive technology (ART) cycles"},{"name":"Infertility due to inadequate luteal phase"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":29,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Crinone %8 vaginal progesterone gel"],"phase":"marketed","status":"active","brandName":"Progesterone Vaginal Gel [Crinone]","genericName":"Progesterone Vaginal Gel [Crinone]","companyName":"Memorial Sisli Hospital, Istanbul","companyId":"memorial-sisli-hospital-istanbul","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Progesterone binds to progesterone receptors in the uterus to support the luteal phase and maintain pregnancy. Used for Luteal phase support in assisted reproductive technology (ART) cycles, Infertility due to inadequate luteal phase.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}