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Progesterone 100 IM/day
Progesterone binds to progesterone receptors in the uterus and other reproductive tissues to prepare and maintain the endometrium for embryo implantation and pregnancy.
Progesterone binds to progesterone receptors in the uterus and other reproductive tissues to prepare and maintain the endometrium for embryo implantation and pregnancy. Used for Luteal phase support in assisted reproductive technology (ART) and fertility treatment, Threatened or recurrent miscarriage prevention.
At a glance
| Generic name | Progesterone 100 IM/day |
|---|---|
| Sponsor | Mansoura Integrated Fertility Center |
| Drug class | Progestin; steroid hormone |
| Target | Progesterone receptor (PR) |
| Modality | Small molecule |
| Therapeutic area | Reproductive/Fertility |
| Phase | FDA-approved |
Mechanism of action
Progesterone is a naturally occurring steroid hormone that acts as a ligand for intracellular progesterone receptors (PR-A and PR-B). Upon binding, it modulates gene transcription to induce secretory changes in the endometrium, suppress uterine contractions, and maintain the corpus luteum, thereby supporting early pregnancy establishment and continuation.
Approved indications
- Luteal phase support in assisted reproductive technology (ART) and fertility treatment
- Threatened or recurrent miscarriage prevention
Common side effects
- Injection site pain or irritation
- Breast tenderness
- Bloating or abdominal discomfort
- Mood changes
- Headache
Key clinical trials
- To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001) (PHASE3)
- Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? RCT (NA)
- The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer (PHASE4)
- Progestin Primed Double Stimulation Protocol Versus Flexible GnRH Antagonist Protocol in Poor Responders (PHASE3)
- Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05690 (Care Program) (P05710)
- Follow-up Protocol on the Outcome of Frozen-thawed Embryo Transfer Cycles From Clinical Trial P05690 (P05711)
- Comparing IM vs. Vaginal Progesterone for Pre-term Birth (NA)
- Evaluation of Different Luteal Phase Support Methods in Patients With Poor Ovarian Response (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Progesterone 100 IM/day CI brief — competitive landscape report
- Progesterone 100 IM/day updates RSS · CI watch RSS
- Mansoura Integrated Fertility Center portfolio CI