{"id":"progesterone-100-im-day","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or irritation"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Bloating or abdominal discomfort"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL103","moleculeType":"Small molecule","molecularWeight":"314.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Progesterone is a naturally occurring steroid hormone that acts as a ligand for intracellular progesterone receptors (PR-A and PR-B). Upon binding, it modulates gene transcription to induce secretory changes in the endometrium, suppress uterine contractions, and maintain the corpus luteum, thereby supporting early pregnancy establishment and continuation.","oneSentence":"Progesterone binds to progesterone receptors in the uterus and other reproductive tissues to prepare and maintain the endometrium for embryo implantation and pregnancy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:47.346Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Luteal phase support in assisted reproductive technology (ART) and fertility treatment"},{"name":"Threatened or recurrent miscarriage prevention"}]},"trialDetails":[{"nctId":"NCT00702845","phase":"PHASE3","title":"To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-12-28","conditions":"Infertility","enrollment":397},{"nctId":"NCT01790282","phase":"NA","title":"Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? 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Used for Luteal phase support in assisted reproductive technology (ART) and fertility treatment, Threatened or recurrent miscarriage prevention.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}