Last reviewed 2026-04-23 · How we verify

Prochlorperazine Injection

Prochlorperazine injection works by blocking dopamine receptors in the brain, which helps to reduce nausea and vomiting.

Prochlorperazine injection works by blocking dopamine receptors in the brain, which helps to reduce nausea and vomiting. Used for Prevention and treatment of nausea and vomiting caused by cancer chemotherapy.

At a glance

Mechanism of action

By blocking dopamine receptors, prochlorperazine injection reduces the activity of the vomiting center in the brain, leading to a decrease in nausea and vomiting. This is particularly useful in patients undergoing chemotherapy or experiencing other forms of nausea and vomiting.

Approved indications

• Prevention and treatment of nausea and vomiting caused by cancer chemotherapy

Common side effects

• Drowsiness
• Dizziness
• Headache

Key clinical trials

• Magnesium Versus Prochlorperazine Versus Metoclopramide for Migraines (PHASE3)
• Paracervical Injection for Headache in the Emergency Department (PHASE2)
• Bupivacaine for Benign Headache in the ED (PHASE2)
• SPG Block for Acute Pediatric Migraine (PHASE3)
• Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting (MK-0517-031) (PHASE3)

Primary sources

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