{"id":"prochlorperazine-injection","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Drowsiness"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1201154","moleculeType":"Small molecule","molecularWeight":"564.15"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By blocking dopamine receptors, prochlorperazine injection reduces the activity of the vomiting center in the brain, leading to a decrease in nausea and vomiting. This is particularly useful in patients undergoing chemotherapy or experiencing other forms of nausea and vomiting.","oneSentence":"Prochlorperazine injection works by blocking dopamine receptors in the brain, which helps to reduce nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:51:55.247Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention and treatment of nausea and vomiting caused by cancer chemotherapy"}]},"trialDetails":[{"nctId":"NCT05967442","phase":"PHASE3","title":"Magnesium Versus Prochlorperazine Versus Metoclopramide for Migraines","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2019-08-23","conditions":"Migraine, Headache","enrollment":157},{"nctId":"NCT04109885","phase":"PHASE2","title":"Paracervical Injection for Headache in the Emergency Department","status":"TERMINATED","sponsor":"Christian Fromm, MD","startDate":"2020-09-15","conditions":"Headache Disorders, Primary, Pain Management, Emergency Department","enrollment":19},{"nctId":"NCT01785459","phase":"PHASE2","title":"Bupivacaine for Benign Headache in the ED","status":"TERMINATED","sponsor":"Wake Forest University Health Sciences","startDate":"2013-10","conditions":"Benign Headache","enrollment":23},{"nctId":"NCT03984045","phase":"PHASE3","title":"SPG Block for Acute Pediatric Migraine","status":"UNKNOWN","sponsor":"Newark Beth Israel Medical Center","startDate":"2019-06-06","conditions":"Migraine in Children, Sphenopalatine Neuralgia, Migraine in Adolescence","enrollment":72},{"nctId":"NCT01594749","phase":"PHASE3","title":"Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting (MK-0517-031)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2012-09-24","conditions":"Chemotherapy-Induced Nausea and Vomiting (CINV)","enrollment":1015}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Prochlorperazine Injection","genericName":"Prochlorperazine Injection","companyName":"Newark Beth Israel Medical Center","companyId":"newark-beth-israel-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prochlorperazine injection works by blocking dopamine receptors in the brain, which helps to reduce nausea and vomiting. Used for Prevention and treatment of nausea and vomiting caused by cancer chemotherapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}