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procaine penicillin and gentamicin

Aga Khan University · Phase 3 active Small molecule

Procaine penicillin acts as a prodrug of penicillin G, which inhibits bacterial cell wall synthesis, while gentamicin is an aminoglycoside antibiotic that inhibits protein synthesis.

Procaine penicillin acts as a prodrug of penicillin G, which inhibits bacterial cell wall synthesis, while gentamicin is an aminoglycoside antibiotic that inhibits protein synthesis. Used for Treatment of bacterial infections, including pneumonia, meningitis, and septicemia.

At a glance

Generic nameprocaine penicillin and gentamicin
SponsorAga Khan University
Drug classPenicillin antibiotic and aminoglycoside antibiotic
TargetPenicillin-binding proteins (PBPs), bacterial ribosome
ModalitySmall molecule
Therapeutic areaInfectious diseases
PhasePhase 3

Mechanism of action

Procaine penicillin is a water-soluble ester prodrug of penicillin G, which is converted to penicillin G in the body. Penicillin G then binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, resulting in the disruption of the bacterial cell wall synthesis and ultimately leading to bacterial cell death. Gentamicin, on the other hand, is an aminoglycoside antibiotic that binds to the 30S subunit of the bacterial ribosome, thereby inhibiting protein synthesis and leading to bacterial cell death.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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