Last reviewed 2026-04-20 · How we verify

Isocain (PROCAINE)

At a glance

Approved indications

• Tattoo Removal
• Waxing
• Hair Removal

Common side effects

• Nervousness
• Dizziness
• Blurred vision
• Tremors
• Drowsiness
• Sweating
• Feeling of faintness
• Cutaneous lesions
• Urticaria
• Edema
• Localized puffiness
• Localized swelling

Serious adverse events

• Convulsions
• Unconsciousness
• Respiratory arrest
• Cerebral hypoxia
• Seizure
• Cardiovascular catastrophe
• Anaphylactoid reactions

Key clinical trials

• Oral Amoxicillin Compared to Penicillin G Benzathine for the Treatment of Acquired Syphilis. (PHASE3)
• § Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis (PHASE3)
• Exploring Long-term Pain Relief with 5% Dextrose Added to Local Anesthetic (NA)
• Virtual Reality in Plastic Surgery: Pain Control and Augmented Satisfaction
• Trial to Assess Chelation Therapy in Critical Limb Ischemia (PHASE3)
• Efficacy of the Use of Cellular Matrix/ A-CP-HA Kit (PHASE4)
• A Prospective Clinical Study on the Safety and Efficacy of Radiofrequency Ablation for the Treatment of Patients With Desmoid Tumors (NA)
• Mesotherapy in the Treatment of Chronic Migraine (NA)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Isocain CI brief — competitive landscape report
• Isocain updates RSS · CI watch RSS
• Pfizer portfolio CI