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Prilocaine (Hyperbaric 2%)
Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Spinal anesthesia for surgical procedures, Local infiltration anesthesia.
At a glance
| Generic name | Prilocaine (Hyperbaric 2%) |
|---|---|
| Also known as | Hyperbaric prilocaine |
| Sponsor | Guy's and St Thomas' NHS Foundation Trust |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Prilocaine works by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, which prevents depolarization and action potential generation. This results in local loss of sensation in the area where it is administered. The hyperbaric formulation (2%) is prepared with dextrose to increase its specific gravity, allowing it to settle dependently in the cerebrospinal fluid when used for spinal anesthesia.
Approved indications
- Spinal anesthesia for surgical procedures
- Local infiltration anesthesia
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Transient neurological symptoms
- Methemoglobinemia (rare, dose-dependent)
Key clinical trials
- Using Three Different Doses of Hyperbaric Prilocaine 2% Local Anaesthetic ( 40,50 and 60mg ),Through Spinal Anaesthesia in Knee Arthroscopy Patients to Compare Time to Void (PHASE3)
- Intrathecal Prilocaine and Adductor Canal Block vs Intrathecal Bupivacaine Alone for Ambulatory Knee Arthroscopy (PHASE4)
- Effect of Subarachnoid Block and Femoropopliteal Block to Limb Perfusion in PAD Patients (NA)
- Hyperbaric Prilocaine 2% vs Hyperbaric Bupivacaine 0.5% in Caesarean Section (EARLY_PHASE1)
- A Comparative Study on Three Different Doses of Intrathecal Hyperbaric Prilocaine With Fentanyl for Optimal Dose to be Used in Elderly Patients Undergoing Day Case Lower Abdominal and Urologic Surgeries. (PHASE3)
- Hyperbaric Prilocaine Compared With Hyperbaric Bupivacaine in Cervical Cerclage? (PHASE4)
- Effect of Prilocaine on Motor Block During Caesarean Section (PHASE4)
- Selective Spinal Anaesthesia With Hyperbaric Prilocain With 2%Provides Better Perioperative Hemodynamic Stability for Patients With Peripheral Vascular Disease and Cardiac Dysfunction in Lower Limb Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Prilocaine (Hyperbaric 2%) CI brief — competitive landscape report
- Prilocaine (Hyperbaric 2%) updates RSS · CI watch RSS
- Guy's and St Thomas' NHS Foundation Trust portfolio CI