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PRILOCAINE HYDROCHLORIDE
Prilocaine Hydrochloride is a marketed local anesthetic primarily used in dentistry, with a key composition patent expiring in 2028. Its established presence in dental procedures provides a stable revenue stream and a recognized brand in the local anesthesia market. The primary risk is the patent expiry in 2028, which could lead to increased competition from generic alternatives.
At a glance
| Generic name | PRILOCAINE HYDROCHLORIDE |
|---|---|
| Modality | Small molecule |
| Phase | FDA-approved |
| First approval | 1965 |
Approved indications
- Local anesthesia in dentistry
Common side effects
- Drowsiness
- Dizziness
- Lightheadedness
- Nervousness
- Apprehension
- Confusion
- Blurred vision
- Double vision
- Vomiting
- Tinnitus
- Numbness
- Sensations of heat
Serious adverse events
- Convulsions
- Respiratory depression
- Respiratory arrest
- Unconsciousness
- Cardiovascular collapse
- Cardiac arrest
- Persistent paresthesia
- Anaphylactoid reactions
- Cerebral hypoxia
- Seizure
Key clinical trials
- Efficacy and Safety of Combined Nanofat Injection With Either Platelet Rich Fibrin or Microneedling Versus Nanofat Injection Alone in the Treatment of Facial Atrophic Post Acne Scars (NA)
- Effect of Erector Spinae Plane Block on Cerebral Oxygenation During One-Lung Ventilation (NA)
- Does Botulinum Toxin Type-A Injection an Effective Way of Relieving Pain in Myofascial Pain Syndrome Patients or Not (NA)
- Combined Adductor&Sciatic Nerve Block vs Femoral&Sciatic Nerve Block in Total Knee Replacement Surgery (NA)
- RIB for Perioperative Analgesia in CIED Patients (NA)
- Effect of Subarachnoid Block and Femoropopliteal Block to Limb Perfusion in PAD Patients (NA)
- A Comparative Study on Three Different Doses of Intrathecal Hyperbaric Prilocaine With Fentanyl for Optimal Dose to be Used in Elderly Patients Undergoing Day Case Lower Abdominal and Urologic Surgeries. (PHASE3)
- Pain Control Following Total Hip Arthroplasty (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- PRILOCAINE HYDROCHLORIDE CI brief — competitive landscape report
- PRILOCAINE HYDROCHLORIDE updates RSS · CI watch RSS