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prilocaine 1%

Helios Research Center · FDA-approved active Small molecule

prilocaine 1% is a Local anesthetic (amide) Small molecule drug developed by Helios Research Center. It is currently FDA-approved for Local anesthesia for infiltration, nerve blocks, and topical application, Dental anesthesia, Minor surgical procedures requiring local anesthesia. Also known as: Xylonest 1%, Xylonest, Citanest.

Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.

Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve blocks, and topical application, Dental anesthesia, Minor surgical procedures requiring local anesthesia.

At a glance

Generic nameprilocaine 1%
Also known asXylonest 1%, Xylonest, Citanest
SponsorHelios Research Center
Drug classLocal anesthetic (amide)
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia
PhaseFDA-approved

Mechanism of action

Prilocaine works by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, which prevents depolarization and action potential generation. This blocks pain signal transmission in localized tissues where it is applied or injected. As an amide-type local anesthetic, it has intermediate onset and duration of action compared to other local anesthetics.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about prilocaine 1%

What is prilocaine 1%?

prilocaine 1% is a Local anesthetic (amide) drug developed by Helios Research Center, indicated for Local anesthesia for infiltration, nerve blocks, and topical application, Dental anesthesia, Minor surgical procedures requiring local anesthesia.

How does prilocaine 1% work?

Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.

What is prilocaine 1% used for?

prilocaine 1% is indicated for Local anesthesia for infiltration, nerve blocks, and topical application, Dental anesthesia, Minor surgical procedures requiring local anesthesia.

Who makes prilocaine 1%?

prilocaine 1% is developed and marketed by Helios Research Center (see full Helios Research Center pipeline at /company/helios-research-center).

Is prilocaine 1% also known as anything else?

prilocaine 1% is also known as Xylonest 1%, Xylonest, Citanest.

What drug class is prilocaine 1% in?

prilocaine 1% belongs to the Local anesthetic (amide) class. See all Local anesthetic (amide) drugs at /class/local-anesthetic-amide.

What development phase is prilocaine 1% in?

prilocaine 1% is FDA-approved (marketed).

What are the side effects of prilocaine 1%?

Common side effects of prilocaine 1% include Methemoglobinemia, Allergic reactions, Systemic toxicity (CNS and cardiac effects at high doses), Local tissue irritation or pain at injection site.

What does prilocaine 1% target?

prilocaine 1% targets Voltage-gated sodium channels and is a Local anesthetic (amide).

Related

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing