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PRGF/ATV
PRGF/ATV is a platelet-rich growth factor combined with autologous tenocyte therapy designed to promote tissue regeneration and repair.
PRGF/ATV is a platelet-rich growth factor combined with autologous tenocyte therapy designed to promote tissue regeneration and repair. Used for Tendon injuries and degenerative conditions, Soft tissue repair and regeneration.
At a glance
| Generic name | PRGF/ATV |
|---|---|
| Also known as | platelets rich in growth factors |
| Sponsor | Ain Shams University |
| Drug class | Autologous cell/tissue therapy with growth factor concentrate |
| Modality | Small molecule |
| Therapeutic area | Orthopedics / Regenerative Medicine |
| Phase | FDA-approved |
Mechanism of action
PRGF (Plasma Rich in Growth Factors) is an autologous blood-derived product containing concentrated growth factors that stimulate healing and tissue regeneration. When combined with ATV (autologous tenocyte therapy), it leverages both the growth factor milieu and viable tenocytes to enhance tendon and soft tissue repair through paracrine signaling and direct cellular regeneration mechanisms.
Approved indications
- Tendon injuries and degenerative conditions
- Soft tissue repair and regeneration
Common side effects
- Local injection site reactions
- Mild inflammation
- Infection risk (minimal with proper sterile technique)
Key clinical trials
- Socket Augmentation Using Atorvastatin With Or Without PRGF (Clinical and Histomorphometric Study) (PHASE4)
- Socket Augmentation Using Platelet Concentrates, Atorvastatin Gel or Combination (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- PRGF/ATV CI brief — competitive landscape report
- PRGF/ATV updates RSS · CI watch RSS
- Ain Shams University portfolio CI