{"id":"prgf-atv","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions"},{"rate":null,"effect":"Mild inflammation"},{"rate":null,"effect":"Infection risk (minimal with proper sterile technique)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PRGF (Plasma Rich in Growth Factors) is an autologous blood-derived product containing concentrated growth factors that stimulate healing and tissue regeneration. When combined with ATV (autologous tenocyte therapy), it leverages both the growth factor milieu and viable tenocytes to enhance tendon and soft tissue repair through paracrine signaling and direct cellular regeneration mechanisms.","oneSentence":"PRGF/ATV is a platelet-rich growth factor combined with autologous tenocyte therapy designed to promote tissue regeneration and repair.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:02:37.856Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tendon injuries and degenerative conditions"},{"name":"Soft tissue repair and regeneration"}]},"trialDetails":[{"nctId":"NCT03228771","phase":"PHASE4","title":"Socket Augmentation Using Atorvastatin With Or Without PRGF (Clinical and Histomorphometric Study)","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2016-03","conditions":"Socket Preservation","enrollment":30},{"nctId":"NCT03231137","phase":"PHASE4","title":"Socket Augmentation Using Platelet Concentrates, Atorvastatin Gel or Combination","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2012-06-16","conditions":"Alveolar Socket Preservations","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["platelets rich in growth factors"],"phase":"marketed","status":"active","brandName":"PRGF/ATV","genericName":"PRGF/ATV","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PRGF/ATV is a platelet-rich growth factor combined with autologous tenocyte therapy designed to promote tissue regeneration and repair. Used for Tendon injuries and degenerative conditions, Soft tissue repair and regeneration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}