Last reviewed 2026-04-22 · How we verify

PRF is added in the test group.

PRF (Platelet-Rich Fibrin) is a biomaterial derived from patient blood that concentrates platelets and growth factors to promote tissue regeneration and healing.

PRF (Platelet-Rich Fibrin) is a biomaterial derived from patient blood that concentrates platelets and growth factors to promote tissue regeneration and healing. Used for Bone and soft tissue regeneration in dental and oral surgery, Wound healing and tissue repair, Orthopedic and maxillofacial applications.

At a glance

Mechanism of action

PRF is prepared by centrifuging whole blood to separate and concentrate platelets, leukocytes, and fibrin into a matrix. When applied to tissue defects, it releases growth factors (PDGF, VEGF, TGF-β) and cytokines that stimulate angiogenesis, collagen deposition, and cellular proliferation, accelerating wound healing and tissue repair.

Approved indications

• Bone and soft tissue regeneration in dental and oral surgery
• Wound healing and tissue repair
• Orthopedic and maxillofacial applications

Common side effects

• Infection at application site
• Inflammation
• Allergic reaction

Key clinical trials

• Clinical and Radiographic Assessment of Platelet Rich Fibrin and Mineral Trioxide Aggregate as Pulp Capping Biomaterials (NA)
• Ultrasonographic Assessment of Palatal Wound Healing
• The Use of Platelet-rich Fibrin (PRF) Membranes in Lateral Alveolar Ridge Augmentation When Jaw Bone is Missing Before Dental Implant Installation. A Study Comparing an Autogenous Bone Block Graft Covered Either by a (PRF) Membrane (Test) or Bone Substitute and a Barrier Membrane (Control) (PHASE4)

Primary sources

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