{"id":"prf-is-added-in-the-test-group","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at application site"},{"rate":null,"effect":"Inflammation"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":{"chemblId":"CHEMBL2108795","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PRF is prepared by centrifuging whole blood to separate and concentrate platelets, leukocytes, and fibrin into a matrix. When applied to tissue defects, it releases growth factors (PDGF, VEGF, TGF-β) and cytokines that stimulate angiogenesis, collagen deposition, and cellular proliferation, accelerating wound healing and tissue repair.","oneSentence":"PRF (Platelet-Rich Fibrin) is a biomaterial derived from patient blood that concentrates platelets and growth factors to promote tissue regeneration and healing.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:34.462Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bone and soft tissue regeneration in dental and oral surgery"},{"name":"Wound healing and tissue repair"},{"name":"Orthopedic and maxillofacial applications"}]},"trialDetails":[{"nctId":"NCT04488679","phase":"NA","title":"Clinical and Radiographic Assessment of Platelet Rich Fibrin and Mineral Trioxide Aggregate as Pulp Capping Biomaterials","status":"COMPLETED","sponsor":"Rahma Ahmed Ibrahem Hafiz","startDate":"2022-09-05","conditions":"Direct Pulp Capping","enrollment":108},{"nctId":"NCT06118177","phase":"","title":"Ultrasonographic Assessment of Palatal Wound Healing","status":"COMPLETED","sponsor":"Pamukkale University","startDate":"2022-09-05","conditions":"Gingival Recession, Palate; Wound","enrollment":20},{"nctId":"NCT04350749","phase":"PHASE4","title":"The Use of Platelet-rich Fibrin (PRF) Membranes in Lateral Alveolar Ridge Augmentation When Jaw Bone is Missing Before Dental Implant Installation. A Study Comparing an Autogenous Bone Block Graft Covered Either by a (PRF) Membrane (Test) or Bone Substitute and a Barrier Membrane (Control)","status":"COMPLETED","sponsor":"University of Aarhus","startDate":"2015-01-15","conditions":"Tooth-loss","enrollment":27}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"PRF is added in the test group.","genericName":"PRF is added in the test group.","companyName":"University of Aarhus","companyId":"university-of-aarhus","modality":"Biologic","firstApprovalDate":"","aiSummary":"Platelet Rich Fibrin (PRF) is added in the test group of a clinical study to assess its effectiveness as a pulp capping biomaterial. The study, NCT04488679, is investigating the use of PRF and Mineral Trioxide Aggregate for direct pulp capping in various dental conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}