Last reviewed · How we verify
Preventative Medication (PM)
Prevents cardiovascular events by inhibiting platelet aggregation.
Prevents cardiovascular events by inhibiting platelet aggregation. Used for Prevention of cardiovascular events in patients at high risk of heart attack or stroke.
At a glance
| Generic name | Preventative Medication (PM) |
|---|---|
| Also known as | Topiramate |
| Sponsor | NYU Langone Health |
| Drug class | antiplatelet |
| Target | COX-1 |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Aspirin works by irreversibly inhibiting the enzyme cyclooxygenase-1 (COX-1), which is responsible for the production of thromboxane A2, a potent stimulator of platelet aggregation. This leads to a decrease in the formation of blood clots and a subsequent reduction in the risk of cardiovascular events such as heart attacks and strokes.
Approved indications
- Prevention of cardiovascular events in patients at high risk of heart attack or stroke
Common side effects
- Gastrointestinal bleeding
- Gastrointestinal upset
Key clinical trials
- Outpatient Administration of Teclistamab or Talquetamab for Multiple Myeloma (PHASE2)
- Prevention of Delirium in ICU Using Multimodal Interventions (NA)
- Positive Minds Strong Bodies Implementation (NA)
- A Digital Health Program for Non-Communicable Disease Prevention in a Workplace Setting in Thailand (NA)
- A Multicomponent Intervention for Prevention and Treatment of Sleep Disturbances in a Psychiatric Intensive Care Unit (NA)
- A Software to Prevent Delirium (PREVEDEL) in Hospitalized Older Adults (NA)
- Multi-dose Ibuprofen Prophylaxis for IUD-insertion (NA)
- Non-invasive Vagus Nerve Stimulation for the Prevention of Migraines (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Preventative Medication (PM) CI brief — competitive landscape report
- Preventative Medication (PM) updates RSS · CI watch RSS
- NYU Langone Health portfolio CI