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preoperative vaginal misoprostol
Misoprostol is a prostaglandin E1 analogue that stimulates uterine contractions and cervical ripening when administered vaginally before labor induction or surgical procedures.
Misoprostol is a prostaglandin E1 analogue that stimulates uterine contractions and cervical ripening when administered vaginally before labor induction or surgical procedures. Used for Preoperative cervical ripening and labor induction, Preparation for surgical procedures requiring cervical dilation.
At a glance
| Generic name | preoperative vaginal misoprostol |
|---|---|
| Also known as | cytotec |
| Sponsor | Ain Shams Maternity Hospital |
| Drug class | Prostaglandin E1 analogue |
| Target | Prostaglandin E receptor (EP receptor) |
| Modality | Small molecule |
| Therapeutic area | Obstetrics/Gynecology |
| Phase | FDA-approved |
Mechanism of action
Misoprostol binds to prostaglandin receptors on uterine smooth muscle, increasing intracellular calcium and promoting myometrial contractions. It also softens and dilates the cervix by promoting collagen remodeling and increasing local blood flow. In the preoperative setting, vaginal administration allows for sustained local drug delivery and gradual cervical preparation.
Approved indications
- Preoperative cervical ripening and labor induction
- Preparation for surgical procedures requiring cervical dilation
Common side effects
- Uterine hyperstimulation
- Abdominal pain/cramping
- Vaginal bleeding
- Diarrhea
- Nausea
Key clinical trials
- Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section (PHASE3)
- Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy (PHASE3)
- Methods to Reduce Blood Loss in Abdominal Myomectomy (PHASE4)
- The Efficacy and Safety of Preoperative Misoprostol in Blood-loss Reduction During Myomectomy. (PHASE2, PHASE3)
- Vaginal Misoprostol Versus Bilateral Uterine Artery Ligation in Decreasing Blood Loss in Trans-abdominal Myomectomy (PHASE4)
- Misoprostol Administration Before Operative Hysteroscopy (PHASE3)
- Misoprostol For Nulliparous Women Before Hysteroscopy (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- preoperative vaginal misoprostol CI brief — competitive landscape report
- preoperative vaginal misoprostol updates RSS · CI watch RSS
- Ain Shams Maternity Hospital portfolio CI