{"id":"preoperative-vaginal-misoprostol","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine hyperstimulation"},{"rate":null,"effect":"Abdominal pain/cramping"},{"rate":null,"effect":"Vaginal bleeding"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL4064157","moleculeType":"Small molecule","molecularWeight":"382.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Misoprostol binds to prostaglandin receptors on uterine smooth muscle, increasing intracellular calcium and promoting myometrial contractions. It also softens and dilates the cervix by promoting collagen remodeling and increasing local blood flow. In the preoperative setting, vaginal administration allows for sustained local drug delivery and gradual cervical preparation.","oneSentence":"Misoprostol is a prostaglandin E1 analogue that stimulates uterine contractions and cervical ripening when administered vaginally before labor induction or surgical procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:27.341Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Preoperative cervical ripening and labor induction"},{"name":"Preparation for surgical procedures requiring cervical dilation"}]},"trialDetails":[{"nctId":"NCT06765473","phase":"PHASE3","title":"Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-01-01","conditions":"Postpartum Hemorrhage","enrollment":400},{"nctId":"NCT05761418","phase":"PHASE3","title":"Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy","status":"COMPLETED","sponsor":"Beni-Suef University","startDate":"2018-03-01","conditions":"Myoma;Uterus","enrollment":90},{"nctId":"NCT04595812","phase":"PHASE4","title":"Methods to Reduce Blood Loss in Abdominal Myomectomy","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2020-11-01","conditions":"Abdominal Myomectomy, Blood Loss","enrollment":120},{"nctId":"NCT03509168","phase":"PHASE2, PHASE3","title":"The Efficacy and Safety of Preoperative Misoprostol in Blood-loss Reduction During Myomectomy.","status":"UNKNOWN","sponsor":"Makerere University","startDate":"2018-01-10","conditions":"Uterine Fibroid","enrollment":46},{"nctId":"NCT02643186","phase":"PHASE4","title":"Vaginal Misoprostol Versus Bilateral Uterine Artery Ligation in Decreasing Blood Loss in Trans-abdominal Myomectomy","status":"UNKNOWN","sponsor":"Ain Shams Maternity Hospital","startDate":"2015-07","conditions":"Vaginal Misoprostol and Bilateral Uterine Artery Ligation in Decreasing Blood Loss in Trans-abdominal Myomectomy","enrollment":62},{"nctId":"NCT01805115","phase":"PHASE3","title":"Misoprostol Administration Before Operative Hysteroscopy","status":"COMPLETED","sponsor":"CHA University","startDate":"2013-03","conditions":"Endometrial Disorder","enrollment":120},{"nctId":"NCT01156948","phase":"PHASE3","title":"Misoprostol For Nulliparous Women Before Hysteroscopy","status":"UNKNOWN","sponsor":"Wenzhou Medical University","startDate":"2008-05","conditions":"Cervical Ripening","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["cytotec"],"phase":"marketed","status":"active","brandName":"preoperative vaginal misoprostol","genericName":"preoperative vaginal misoprostol","companyName":"Ain Shams Maternity Hospital","companyId":"ain-shams-maternity-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Misoprostol is a prostaglandin E1 analogue that stimulates uterine contractions and cervical ripening when administered vaginally before labor induction or surgical procedures. Used for Preoperative cervical ripening and labor induction, Preparation for surgical procedures requiring cervical dilation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}