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preoperative budesonide inhalation
Budesonide is an inhaled corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors and suppressing inflammatory mediator production.
Budesonide is an inhaled corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors and suppressing inflammatory mediator production. Used for Preoperative airway inflammation reduction in patients undergoing surgery, Asthma and chronic obstructive pulmonary disease maintenance therapy.
At a glance
| Generic name | preoperative budesonide inhalation |
|---|---|
| Sponsor | Fujian Medical University Union Hospital |
| Drug class | Inhaled corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | FDA-approved |
Mechanism of action
Budesonide acts as a selective glucocorticoid receptor agonist in the lungs, decreasing production of inflammatory cytokines, chemokines, and adhesion molecules. When administered preoperatively via inhalation, it reduces airway hyperresponsiveness and inflammation, potentially decreasing perioperative respiratory complications in susceptible patients.
Approved indications
- Preoperative airway inflammation reduction in patients undergoing surgery
- Asthma and chronic obstructive pulmonary disease maintenance therapy
Common side effects
- Tremor
- Headache
- Throat irritation
- Hoarseness
- Oral candidiasis
Key clinical trials
- Comparison of Preoperative Inhaled Budesonide With Salbutamol on the Respiratory Adverse Effects in Children Undergoing Tonsillectomy (PHASE4)
- Effect of Preoperative Budesonide Inhalation on Arterial Blood Oxygenation and Intrapulmonary Shunt During OLV (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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