{"id":"preoperative-budesonide-inhalation","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Hoarseness"},{"rate":null,"effect":"Oral candidiasis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Budesonide acts as a selective glucocorticoid receptor agonist in the lungs, decreasing production of inflammatory cytokines, chemokines, and adhesion molecules. When administered preoperatively via inhalation, it reduces airway hyperresponsiveness and inflammation, potentially decreasing perioperative respiratory complications in susceptible patients.","oneSentence":"Budesonide is an inhaled corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors and suppressing inflammatory mediator production.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:28.828Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Preoperative airway inflammation reduction in patients undergoing surgery"},{"name":"Asthma and chronic obstructive pulmonary disease maintenance therapy"}]},"trialDetails":[{"nctId":"NCT06158893","phase":"PHASE4","title":"Comparison of Preoperative Inhaled Budesonide With Salbutamol on the Respiratory Adverse Effects in Children Undergoing Tonsillectomy","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2024-08","conditions":"Preoperative Inhalation of Budesonide and Salbutamol in Children Undergoing Tonsillectomy","enrollment":87},{"nctId":"NCT03394222","phase":"PHASE4","title":"Effect of Preoperative Budesonide Inhalation on Arterial Blood Oxygenation and Intrapulmonary Shunt During OLV","status":"COMPLETED","sponsor":"Fujian Medical University Union Hospital","startDate":"2016-07","conditions":"Lung Cancer","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"preoperative budesonide inhalation","genericName":"preoperative budesonide inhalation","companyName":"Fujian Medical University Union Hospital","companyId":"fujian-medical-university-union-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Budesonide is an inhaled corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors and suppressing inflammatory mediator production. Used for Preoperative airway inflammation reduction in patients undergoing surgery, Asthma and chronic obstructive pulmonary disease maintenance therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}