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Preop acetaminophen IV
Preop acetaminophen IV is a Analgesic and antipyretic (non-NSAID) Small molecule drug developed by AdventHealth. It is currently FDA-approved for Preoperative analgesia and fever reduction, Postoperative pain management. Also known as: Ofirmev.
Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system.
Preop acetaminophen IV is used in multimodal analgesic approaches for various conditions, including breast cancer, opioid use, shoulder osteoarthritis, and avascular necrosis. It is administered as a small molecule, either through intravenous or oral routes, as part of an ERAS pathway or as Ofirmev.
At a glance
| Generic name | Preop acetaminophen IV |
|---|---|
| Also known as | Ofirmev |
| Sponsor | AdventHealth |
| Drug class | Analgesic and antipyretic (non-NSAID) |
| Target | Cyclooxygenase (COX) enzymes |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Acetaminophen works primarily through inhibition of cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing the production of prostaglandins that mediate pain and fever signaling. The intravenous formulation provides rapid systemic delivery for perioperative pain management. It is commonly used as a non-opioid analgesic in the preoperative setting to reduce postoperative pain and opioid requirements.
Approved indications
- Preoperative analgesia and fever reduction
- Postoperative pain management
Common side effects
- Hepatotoxicity (at high doses)
- Hypersensitivity reactions
- Infusion site reactions
Key clinical trials
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Anesthetic Optimization in Pediatric LeFort Surgeries (NA)
- IV vs Oral Acetaminophen in Spine Fusion Perioperative Care (PHASE4)
- Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery (PHASE4)
- Multimodal Analgesia in Shoulder Arthroplasty (PHASE3)
- Opioid-Free Shoulder Arthroplasty (PHASE4)
- ERAS in Autologous Breast Reconstruction: A Pilot RCT (NA)
- Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Preop acetaminophen IV CI brief — competitive landscape report
- Preop acetaminophen IV updates RSS · CI watch RSS
- AdventHealth portfolio CI
Frequently asked questions about Preop acetaminophen IV
What is Preop acetaminophen IV?
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Is Preop acetaminophen IV also known as anything else?
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Related
- Drug class: All Analgesic and antipyretic (non-NSAID) drugs
- Target: All drugs targeting Cyclooxygenase (COX) enzymes
- Manufacturer: AdventHealth — full pipeline
- Therapeutic area: All drugs in Pain Management
- Indication: Drugs for Preoperative analgesia and fever reduction
- Indication: Drugs for Postoperative pain management
- Also known as: Ofirmev
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing