{"id":"preop-acetaminophen-iv","safety":{"commonSideEffects":[{"rate":null,"effect":"Hepatotoxicity (at high doses)"},{"rate":null,"effect":"Hypersensitivity reactions"},{"rate":null,"effect":"Infusion site reactions"}]},"_chembl":{"chemblId":"CHEMBL1647","moleculeType":"Small molecule","molecularWeight":"327.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen works primarily through inhibition of cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing the production of prostaglandins that mediate pain and fever signaling. The intravenous formulation provides rapid systemic delivery for perioperative pain management. It is commonly used as a non-opioid analgesic in the preoperative setting to reduce postoperative pain and opioid requirements.","oneSentence":"Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:24.999Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Preoperative analgesia and fever reduction"},{"name":"Postoperative pain management"}]},"trialDetails":[{"nctId":"NCT05488847","phase":"PHASE4","title":"Opioid-Free Pain Protocol After Shoulder Arthroplasty","status":"ACTIVE_NOT_RECRUITING","sponsor":"Henry Ford Health System","startDate":"2022-06-25","conditions":"Shoulder Arthropathy, Shoulder Pain","enrollment":83},{"nctId":"NCT05260320","phase":"NA","title":"Anesthetic Optimization in Pediatric LeFort Surgeries","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2025-05-02","conditions":"Le Fort, Pain, Postoperative","enrollment":50},{"nctId":"NCT03020875","phase":"PHASE4","title":"IV vs Oral Acetaminophen in Spine Fusion Perioperative Care","status":"ENROLLING_BY_INVITATION","sponsor":"Hospital for Special Surgery, New York","startDate":"2017-01","conditions":"Multimodal Analgesic Approach","enrollment":166},{"nctId":"NCT05413902","phase":"PHASE4","title":"Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery","status":"COMPLETED","sponsor":"University of Puerto Rico","startDate":"2021-04-05","conditions":"Pain Management, Posterior Spinal Fusion","enrollment":100},{"nctId":"NCT03586934","phase":"PHASE3","title":"Multimodal Analgesia in Shoulder Arthroplasty","status":"WITHDRAWN","sponsor":"Rush University Medical Center","startDate":"2018-06-01","conditions":"Shoulder Pain, Opioid Use","enrollment":""},{"nctId":"NCT03540030","phase":"PHASE4","title":"Opioid-Free Shoulder Arthroplasty","status":"COMPLETED","sponsor":"OrthoCarolina Research Institute, Inc.","startDate":"2016-09","conditions":"Opioid Use, Shoulder Osteoarthritis, Avascular Necrosis","enrollment":86},{"nctId":"NCT04306003","phase":"NA","title":"ERAS in Autologous Breast Reconstruction: A Pilot RCT","status":"COMPLETED","sponsor":"Hamilton Health Sciences Corporation","startDate":"2019-11-05","conditions":"Breast Cancer","enrollment":20},{"nctId":"NCT02449369","phase":"PHASE4","title":"Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee","status":"COMPLETED","sponsor":"AdventHealth","startDate":"2015-04","conditions":"Unilateral Knee Arthroplasty","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ofirmev"],"phase":"marketed","status":"active","brandName":"Preop acetaminophen IV","genericName":"Preop acetaminophen IV","companyName":"AdventHealth","companyId":"adventhealth","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Preop acetaminophen IV is used in multimodal analgesic approaches for various conditions, including breast cancer, opioid use, shoulder osteoarthritis, and avascular necrosis. It is administered as a small molecule, either through intravenous or oral routes, as part of an ERAS pathway or as Ofirmev.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}