Last reviewed 2026-04-23 · How we verify

Pregabalin + Vitamin B fixed dose

Pregabalin binds to voltage-gated calcium channels to reduce neurotransmitter release, while B vitamins support nerve function and myelin integrity.

Pregabalin binds to voltage-gated calcium channels to reduce neurotransmitter release, while B vitamins support nerve function and myelin integrity. Used for Neuropathic pain (diabetic peripheral neuropathy, postherpetic neuralgia, or other peripheral neuropathies), Generalized anxiety disorder, Partial-onset seizures.

At a glance

Mechanism of action

Pregabalin is a gabapentinoid that binds to the alpha-2-delta subunit of L-type voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters and thereby decreasing neuronal hyperexcitability. The addition of B vitamins (likely B1, B6, B12) provides nutritional support for nerve metabolism and myelin maintenance, potentially enhancing neuroprotection and symptom relief in neuropathic conditions.

Approved indications

• Neuropathic pain (diabetic peripheral neuropathy, postherpetic neuralgia, or other peripheral neuropathies)
• Generalized anxiety disorder
• Partial-onset seizures

Common side effects

• Dizziness
• Somnolence
• Dry mouth
• Edema
• Blurred vision
• Weight gain
• Ataxia

Key clinical trials

• Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain (PHASE3)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Pregabalin + Vitamin B fixed dose CI brief — competitive landscape report
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• Laboratorios Silanes S.A. de C.V. portfolio CI