{"id":"pregabalin-vitamin-b-fixed-dose","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Dizziness"},{"rate":"15-25","effect":"Somnolence"},{"rate":"5-15","effect":"Dry mouth"},{"rate":"5-10","effect":"Edema"},{"rate":"5-10","effect":"Blurred vision"},{"rate":"5-10","effect":"Weight gain"},{"rate":"5-10","effect":"Ataxia"}]},"_chembl":{"chemblId":"CHEMBL1059","moleculeType":"Small molecule","molecularWeight":"159.23"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pregabalin is a gabapentinoid that binds to the alpha-2-delta subunit of L-type voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters and thereby decreasing neuronal hyperexcitability. The addition of B vitamins (likely B1, B6, B12) provides nutritional support for nerve metabolism and myelin maintenance, potentially enhancing neuroprotection and symptom relief in neuropathic conditions.","oneSentence":"Pregabalin binds to voltage-gated calcium channels to reduce neurotransmitter release, while B vitamins support nerve function and myelin integrity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:30:04.605Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain (diabetic peripheral neuropathy, postherpetic neuralgia, or other peripheral neuropathies)"},{"name":"Generalized anxiety disorder"},{"name":"Partial-onset seizures"}]},"trialDetails":[{"nctId":"NCT06516094","phase":"PHASE3","title":"Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain","status":"COMPLETED","sponsor":"Laboratorios Silanes S.A. de C.V.","startDate":"2024-04-11","conditions":"Chronic Low-back Pain","enrollment":192}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Pre+Vit B"],"phase":"phase_3","status":"active","brandName":"Pregabalin + Vitamin B fixed dose","genericName":"Pregabalin + Vitamin B fixed dose","companyName":"Laboratorios Silanes S.A. de C.V.","companyId":"laboratorios-silanes-s-a-de-c-v","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pregabalin binds to voltage-gated calcium channels to reduce neurotransmitter release, while B vitamins support nerve function and myelin integrity. Used for Neuropathic pain (diabetic peripheral neuropathy, postherpetic neuralgia, or other peripheral neuropathies), Generalized anxiety disorder, Partial-onset seizures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}