Last reviewed 2026-04-22 · How we verify

prednison, azithromycin

This combination uses prednisone (a corticosteroid) to suppress immune and inflammatory responses, and azithromycin (a macrolide antibiotic) to treat bacterial infections and modulate immune function.

This combination uses prednisone (a corticosteroid) to suppress immune and inflammatory responses, and azithromycin (a macrolide antibiotic) to treat bacterial infections and modulate immune function. Used for Bacterial infections with concurrent inflammatory conditions, Respiratory tract infections with immune dysregulation.

At a glance

Mechanism of action

Prednisone is a glucocorticoid that inhibits phospholipase A2 and reduces production of inflammatory mediators, suppressing both cellular and humoral immunity. Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis via 50S ribosomal subunit binding, and also possesses immunomodulatory properties including reduction of pro-inflammatory cytokines. Together, they address both infectious and inflammatory components of disease.

Approved indications

• Bacterial infections with concurrent inflammatory conditions
• Respiratory tract infections with immune dysregulation

Common side effects

• Immunosuppression / increased infection risk
• Gastrointestinal disturbance (nausea, diarrhea)
• Hyperglycemia
• Insomnia / mood changes
• QT prolongation (azithromycin)

Key clinical trials

• MSC for Treatment of Interstitial Lung Disease After Allo-HSCT (PHASE1, PHASE2)
• The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease (PHASE4)

Primary sources

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