{"id":"prednison-azithromycin","safety":{"commonSideEffects":[{"rate":null,"effect":"Immunosuppression / increased infection risk"},{"rate":null,"effect":"Gastrointestinal disturbance (nausea, diarrhea)"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Insomnia / mood changes"},{"rate":null,"effect":"QT prolongation (azithromycin)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prednisone is a glucocorticoid that inhibits phospholipase A2 and reduces production of inflammatory mediators, suppressing both cellular and humoral immunity. Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis via 50S ribosomal subunit binding, and also possesses immunomodulatory properties including reduction of pro-inflammatory cytokines. Together, they address both infectious and inflammatory components of disease.","oneSentence":"This combination uses prednisone (a corticosteroid) to suppress immune and inflammatory responses, and azithromycin (a macrolide antibiotic) to treat bacterial infections and modulate immune function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:16.836Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections with concurrent inflammatory conditions"},{"name":"Respiratory tract infections with immune dysregulation"}]},"trialDetails":[{"nctId":"NCT02543073","phase":"PHASE1, PHASE2","title":"MSC for Treatment of Interstitial Lung Disease After Allo-HSCT","status":"UNKNOWN","sponsor":"Nanfang Hospital, Southern Medical University","startDate":"2014-09","conditions":"Lung Diseases, Interstitial, Hematopoietic Stem Cell Transplantation, Bronchiolitis Obliterans","enrollment":60},{"nctId":"NCT01469702","phase":"PHASE4","title":"The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease","status":"UNKNOWN","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2011-12","conditions":"Cat-scratch Disease, Bartonella Infections","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":85,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"prednison, azithromycin","genericName":"prednison, azithromycin","companyName":"Tel-Aviv Sourasky Medical Center","companyId":"tel-aviv-sourasky-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses prednisone (a corticosteroid) to suppress immune and inflammatory responses, and azithromycin (a macrolide antibiotic) to treat bacterial infections and modulate immune function. Used for Bacterial infections with concurrent inflammatory conditions, Respiratory tract infections with immune dysregulation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}