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prednison, Azenil
Prednisone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors.
Prednisone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors. Used for Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis), Allergic reactions and asthma, Adrenal insufficiency.
At a glance
| Generic name | prednison, Azenil |
|---|---|
| Sponsor | Tel-Aviv Sourasky Medical Center |
| Drug class | Corticosteroid (glucocorticoid) |
| Target | Glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Immunology, Rheumatology, Allergy, Endocrinology |
| Phase | FDA-approved |
Mechanism of action
Prednisone acts as a glucocorticoid receptor agonist, translocating to the nucleus and modulating gene expression to decrease production of pro-inflammatory cytokines and immune cell activation. It reduces inflammation, suppresses immune responses, and has broad anti-inflammatory effects across multiple organ systems. This makes it useful for treating autoimmune, inflammatory, and allergic conditions.
Approved indications
- Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis)
- Allergic reactions and asthma
- Adrenal insufficiency
- Certain hematologic malignancies and lymphomas
- Organ transplant rejection prophylaxis
Common side effects
- Hyperglycemia
- Hypertension
- Osteoporosis
- Immunosuppression/increased infection risk
- Insomnia
- Mood changes (anxiety, depression)
- Gastrointestinal upset
- Weight gain
Key clinical trials
- The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- prednison, Azenil CI brief — competitive landscape report
- prednison, Azenil updates RSS · CI watch RSS
- Tel-Aviv Sourasky Medical Center portfolio CI