{"id":"prednison-azenil","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Osteoporosis"},{"rate":null,"effect":"Immunosuppression/increased infection risk"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Mood changes (anxiety, depression)"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Weight gain"}]},"_chembl":{"chemblId":"CHEMBL15720","moleculeType":"Small molecule","molecularWeight":"358.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prednisone acts as a glucocorticoid receptor agonist, translocating to the nucleus and modulating gene expression to decrease production of pro-inflammatory cytokines and immune cell activation. It reduces inflammation, suppresses immune responses, and has broad anti-inflammatory effects across multiple organ systems. This makes it useful for treating autoimmune, inflammatory, and allergic conditions.","oneSentence":"Prednisone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:10.995Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis)"},{"name":"Allergic reactions and asthma"},{"name":"Adrenal insufficiency"},{"name":"Certain hematologic malignancies and lymphomas"},{"name":"Organ transplant rejection prophylaxis"}]},"trialDetails":[{"nctId":"NCT01469702","phase":"PHASE4","title":"The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease","status":"UNKNOWN","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2011-12","conditions":"Cat-scratch Disease, Bartonella Infections","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"prednison, Azenil","genericName":"prednison, Azenil","companyName":"Tel-Aviv Sourasky Medical Center","companyId":"tel-aviv-sourasky-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prednisone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors. Used for Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis), Allergic reactions and asthma, Adrenal insufficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}